Predictive factors for the development of renal insufficiency following partial nephrectomy and subsequent renal function recovery: A multicenter retrospective study

Kwang Suk Lee, Dae Keun Kim, Kwang Hyun Kim, Woo Jin Bang, Hyung Joon Kim, Sung Yul Park, Koon Ho Rha, Byung Ha Chung, Jin Seon Cho, Kyo Chul Koo

Research output: Contribution to journalArticle

Abstract

Patients who undergo partial nephrectomy (PN) may exhibit renal function insufficiency, and a subset of these patients achieves renal function recovery. We evaluated the predictors of renal insufficiency and subsequent renal function recovery following PN. Data on 393 patients who underwent PN for solid renal tumors between March 2001 and November 2013, obtained from 6 institutions, were retrospectively reviewed. Renal insufficiency was defined as new onset of chronic kidney disease stage ≥3 postoperatively on the second of 2 consecutive tests. Renal function recovery was defined as an estimated glomerular filtration rate ≥60ml/minute/1.73m2 following renal insufficiency. Tumor complexity was stratified according to the RENAL classification system. The median (interquartile range) age, tumor size, and follow-up period were 53 (45-63) years, 2.6 (1.9-3.8) cm, and 36 (12-48) months, respectively. Tumors were of low complexity in 258/393 (65.6%) of cases. Renal insufficiency developed in 54/393 (13.5%) patients, in which age ≥60 years and preoperative creatinine ≥1.1mg/ml were independent predictors. Tumor complexity, clamp type, and operative method were not significant prognostic factors. Among patients with newly developed renal insufficiency, 18/54 (33.3%) patients exhibited renal function recovery within a median period of 18 months, of which preoperative creatinine <1.1mg/ml was an independent predictor. Age ≥60 years and preoperative creatinine ≥1.1mg/ml were risk factors for renal insufficiency following PN. Patients with renal insufficiency whose preoperative creatinine was <1.1mg/ml were likely to have renal function recovery.

Original languageEnglish
Article numbere15516
JournalMedicine (United States)
Volume98
Issue number18
DOIs
Publication statusPublished - 2019 May 1

Fingerprint

Recovery of Function
Nephrectomy
Multicenter Studies
Renal Insufficiency
Retrospective Studies
Kidney
Creatinine
Neoplasms
Glomerular Filtration Rate
Chronic Renal Insufficiency

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Kwang Suk ; Kim, Dae Keun ; Kim, Kwang Hyun ; Bang, Woo Jin ; Kim, Hyung Joon ; Park, Sung Yul ; Rha, Koon Ho ; Chung, Byung Ha ; Cho, Jin Seon ; Koo, Kyo Chul. / Predictive factors for the development of renal insufficiency following partial nephrectomy and subsequent renal function recovery : A multicenter retrospective study. In: Medicine (United States). 2019 ; Vol. 98, No. 18.
@article{41301c08f30f4116bb9ebe3617cc35a8,
title = "Predictive factors for the development of renal insufficiency following partial nephrectomy and subsequent renal function recovery: A multicenter retrospective study",
abstract = "Patients who undergo partial nephrectomy (PN) may exhibit renal function insufficiency, and a subset of these patients achieves renal function recovery. We evaluated the predictors of renal insufficiency and subsequent renal function recovery following PN. Data on 393 patients who underwent PN for solid renal tumors between March 2001 and November 2013, obtained from 6 institutions, were retrospectively reviewed. Renal insufficiency was defined as new onset of chronic kidney disease stage ≥3 postoperatively on the second of 2 consecutive tests. Renal function recovery was defined as an estimated glomerular filtration rate ≥60ml/minute/1.73m2 following renal insufficiency. Tumor complexity was stratified according to the RENAL classification system. The median (interquartile range) age, tumor size, and follow-up period were 53 (45-63) years, 2.6 (1.9-3.8) cm, and 36 (12-48) months, respectively. Tumors were of low complexity in 258/393 (65.6{\%}) of cases. Renal insufficiency developed in 54/393 (13.5{\%}) patients, in which age ≥60 years and preoperative creatinine ≥1.1mg/ml were independent predictors. Tumor complexity, clamp type, and operative method were not significant prognostic factors. Among patients with newly developed renal insufficiency, 18/54 (33.3{\%}) patients exhibited renal function recovery within a median period of 18 months, of which preoperative creatinine <1.1mg/ml was an independent predictor. Age ≥60 years and preoperative creatinine ≥1.1mg/ml were risk factors for renal insufficiency following PN. Patients with renal insufficiency whose preoperative creatinine was <1.1mg/ml were likely to have renal function recovery.",
author = "Lee, {Kwang Suk} and Kim, {Dae Keun} and Kim, {Kwang Hyun} and Bang, {Woo Jin} and Kim, {Hyung Joon} and Park, {Sung Yul} and Rha, {Koon Ho} and Chung, {Byung Ha} and Cho, {Jin Seon} and Koo, {Kyo Chul}",
year = "2019",
month = "5",
day = "1",
doi = "10.1097/MD.0000000000015516",
language = "English",
volume = "98",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

Predictive factors for the development of renal insufficiency following partial nephrectomy and subsequent renal function recovery : A multicenter retrospective study. / Lee, Kwang Suk; Kim, Dae Keun; Kim, Kwang Hyun; Bang, Woo Jin; Kim, Hyung Joon; Park, Sung Yul; Rha, Koon Ho; Chung, Byung Ha; Cho, Jin Seon; Koo, Kyo Chul.

In: Medicine (United States), Vol. 98, No. 18, e15516, 01.05.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictive factors for the development of renal insufficiency following partial nephrectomy and subsequent renal function recovery

T2 - A multicenter retrospective study

AU - Lee, Kwang Suk

AU - Kim, Dae Keun

AU - Kim, Kwang Hyun

AU - Bang, Woo Jin

AU - Kim, Hyung Joon

AU - Park, Sung Yul

AU - Rha, Koon Ho

AU - Chung, Byung Ha

AU - Cho, Jin Seon

AU - Koo, Kyo Chul

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Patients who undergo partial nephrectomy (PN) may exhibit renal function insufficiency, and a subset of these patients achieves renal function recovery. We evaluated the predictors of renal insufficiency and subsequent renal function recovery following PN. Data on 393 patients who underwent PN for solid renal tumors between March 2001 and November 2013, obtained from 6 institutions, were retrospectively reviewed. Renal insufficiency was defined as new onset of chronic kidney disease stage ≥3 postoperatively on the second of 2 consecutive tests. Renal function recovery was defined as an estimated glomerular filtration rate ≥60ml/minute/1.73m2 following renal insufficiency. Tumor complexity was stratified according to the RENAL classification system. The median (interquartile range) age, tumor size, and follow-up period were 53 (45-63) years, 2.6 (1.9-3.8) cm, and 36 (12-48) months, respectively. Tumors were of low complexity in 258/393 (65.6%) of cases. Renal insufficiency developed in 54/393 (13.5%) patients, in which age ≥60 years and preoperative creatinine ≥1.1mg/ml were independent predictors. Tumor complexity, clamp type, and operative method were not significant prognostic factors. Among patients with newly developed renal insufficiency, 18/54 (33.3%) patients exhibited renal function recovery within a median period of 18 months, of which preoperative creatinine <1.1mg/ml was an independent predictor. Age ≥60 years and preoperative creatinine ≥1.1mg/ml were risk factors for renal insufficiency following PN. Patients with renal insufficiency whose preoperative creatinine was <1.1mg/ml were likely to have renal function recovery.

AB - Patients who undergo partial nephrectomy (PN) may exhibit renal function insufficiency, and a subset of these patients achieves renal function recovery. We evaluated the predictors of renal insufficiency and subsequent renal function recovery following PN. Data on 393 patients who underwent PN for solid renal tumors between March 2001 and November 2013, obtained from 6 institutions, were retrospectively reviewed. Renal insufficiency was defined as new onset of chronic kidney disease stage ≥3 postoperatively on the second of 2 consecutive tests. Renal function recovery was defined as an estimated glomerular filtration rate ≥60ml/minute/1.73m2 following renal insufficiency. Tumor complexity was stratified according to the RENAL classification system. The median (interquartile range) age, tumor size, and follow-up period were 53 (45-63) years, 2.6 (1.9-3.8) cm, and 36 (12-48) months, respectively. Tumors were of low complexity in 258/393 (65.6%) of cases. Renal insufficiency developed in 54/393 (13.5%) patients, in which age ≥60 years and preoperative creatinine ≥1.1mg/ml were independent predictors. Tumor complexity, clamp type, and operative method were not significant prognostic factors. Among patients with newly developed renal insufficiency, 18/54 (33.3%) patients exhibited renal function recovery within a median period of 18 months, of which preoperative creatinine <1.1mg/ml was an independent predictor. Age ≥60 years and preoperative creatinine ≥1.1mg/ml were risk factors for renal insufficiency following PN. Patients with renal insufficiency whose preoperative creatinine was <1.1mg/ml were likely to have renal function recovery.

UR - http://www.scopus.com/inward/record.url?scp=85065535582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065535582&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000015516

DO - 10.1097/MD.0000000000015516

M3 - Article

C2 - 31045843

AN - SCOPUS:85065535582

VL - 98

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 18

M1 - e15516

ER -