Predictive factors for unfavorable outcomes of tuberculous pericarditis in human immunodeficiency virus-uninfected patients in an intermediate tuberculosis burden country

In Young Jung, Young Goo Song, JunYong Choi, Moo Hyun Kim, Woo Yong Jeong, Dong Hyun Oh, Yong Chan Kim, Je Eun Song, Eun Jin Kim, Ji Un Lee, Su Jin Jeong, Nam Su Ku, June Myung Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country. Methods: A retrospective review of 87 cases of TB pericarditis diagnosed at a tertiary referral hospital in South Korea was performed. Clinical characteristics, treatment outcomes, complications during treatment, duration of treatment, and medication history were reviewed. Unfavorable outcome was defined as constrictive pericarditis identified on echocardiography performed 3 to 6 months after initial diagnosis of TB pericarditis, cardiac tamponade requiring emergency pericardiocentesis, or death. Predictive factors for unfavorable outcomes were identified. Results: Of the 87 patients, 44 (50.6%) had unfavorable outcomes; cardiac tamponade (n = 36), constrictive pericarditis (n = 18), and mortality (n = 4). 14 patients experienced both cardiac tamponade and constrictive pericarditis. During a 1 year out-patient clinic follow up, 4 patients required repeat pericardiocentesis and pericardiectomy was performed in 0 patients. In the multivariate analysis, patients with large amounts of pericardial effusion (P = .003), those with hypoalbuminemia (P = .011), and those without cardiovascular disease (P = .011) were found to have a higher risk of unfavorable outcomes. Conclusion: HIV-uninfected patients with TB pericarditis are at a higher risk for unfavorable outcomes when presenting with low serum albumin, with large pericardial effusions, and without cardiovascular disease.

Original languageEnglish
Article number719
JournalBMC Infectious Diseases
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Nov 29

Fingerprint

Tuberculous Pericarditis
Pericarditis
Tuberculosis
Constrictive Pericarditis
HIV
Cardiac Tamponade
Pericardiocentesis
Pericardial Effusion
Cardiovascular Diseases
Pericardiectomy
Hypoalbuminemia
Republic of Korea
Mortality
Mycobacterium tuberculosis
Tertiary Care Centers
Serum Albumin
Echocardiography
Emergencies
Outpatients
Therapeutics

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Jung, In Young ; Song, Young Goo ; Choi, JunYong ; Kim, Moo Hyun ; Jeong, Woo Yong ; Oh, Dong Hyun ; Kim, Yong Chan ; Song, Je Eun ; Kim, Eun Jin ; Lee, Ji Un ; Jeong, Su Jin ; Ku, Nam Su ; Kim, June Myung. / Predictive factors for unfavorable outcomes of tuberculous pericarditis in human immunodeficiency virus-uninfected patients in an intermediate tuberculosis burden country. In: BMC Infectious Diseases. 2016 ; Vol. 16, No. 1.
@article{7c72e07aea8049e79d550dc446ee8193,
title = "Predictive factors for unfavorable outcomes of tuberculous pericarditis in human immunodeficiency virus-uninfected patients in an intermediate tuberculosis burden country",
abstract = "Background: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country. Methods: A retrospective review of 87 cases of TB pericarditis diagnosed at a tertiary referral hospital in South Korea was performed. Clinical characteristics, treatment outcomes, complications during treatment, duration of treatment, and medication history were reviewed. Unfavorable outcome was defined as constrictive pericarditis identified on echocardiography performed 3 to 6 months after initial diagnosis of TB pericarditis, cardiac tamponade requiring emergency pericardiocentesis, or death. Predictive factors for unfavorable outcomes were identified. Results: Of the 87 patients, 44 (50.6{\%}) had unfavorable outcomes; cardiac tamponade (n = 36), constrictive pericarditis (n = 18), and mortality (n = 4). 14 patients experienced both cardiac tamponade and constrictive pericarditis. During a 1 year out-patient clinic follow up, 4 patients required repeat pericardiocentesis and pericardiectomy was performed in 0 patients. In the multivariate analysis, patients with large amounts of pericardial effusion (P = .003), those with hypoalbuminemia (P = .011), and those without cardiovascular disease (P = .011) were found to have a higher risk of unfavorable outcomes. Conclusion: HIV-uninfected patients with TB pericarditis are at a higher risk for unfavorable outcomes when presenting with low serum albumin, with large pericardial effusions, and without cardiovascular disease.",
author = "Jung, {In Young} and Song, {Young Goo} and JunYong Choi and Kim, {Moo Hyun} and Jeong, {Woo Yong} and Oh, {Dong Hyun} and Kim, {Yong Chan} and Song, {Je Eun} and Kim, {Eun Jin} and Lee, {Ji Un} and Jeong, {Su Jin} and Ku, {Nam Su} and Kim, {June Myung}",
year = "2016",
month = "11",
day = "29",
doi = "10.1186/s12879-016-2062-5",
language = "English",
volume = "16",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",
number = "1",

}

Predictive factors for unfavorable outcomes of tuberculous pericarditis in human immunodeficiency virus-uninfected patients in an intermediate tuberculosis burden country. / Jung, In Young; Song, Young Goo; Choi, JunYong; Kim, Moo Hyun; Jeong, Woo Yong; Oh, Dong Hyun; Kim, Yong Chan; Song, Je Eun; Kim, Eun Jin; Lee, Ji Un; Jeong, Su Jin; Ku, Nam Su; Kim, June Myung.

In: BMC Infectious Diseases, Vol. 16, No. 1, 719, 29.11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictive factors for unfavorable outcomes of tuberculous pericarditis in human immunodeficiency virus-uninfected patients in an intermediate tuberculosis burden country

AU - Jung, In Young

AU - Song, Young Goo

AU - Choi, JunYong

AU - Kim, Moo Hyun

AU - Jeong, Woo Yong

AU - Oh, Dong Hyun

AU - Kim, Yong Chan

AU - Song, Je Eun

AU - Kim, Eun Jin

AU - Lee, Ji Un

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Kim, June Myung

PY - 2016/11/29

Y1 - 2016/11/29

N2 - Background: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country. Methods: A retrospective review of 87 cases of TB pericarditis diagnosed at a tertiary referral hospital in South Korea was performed. Clinical characteristics, treatment outcomes, complications during treatment, duration of treatment, and medication history were reviewed. Unfavorable outcome was defined as constrictive pericarditis identified on echocardiography performed 3 to 6 months after initial diagnosis of TB pericarditis, cardiac tamponade requiring emergency pericardiocentesis, or death. Predictive factors for unfavorable outcomes were identified. Results: Of the 87 patients, 44 (50.6%) had unfavorable outcomes; cardiac tamponade (n = 36), constrictive pericarditis (n = 18), and mortality (n = 4). 14 patients experienced both cardiac tamponade and constrictive pericarditis. During a 1 year out-patient clinic follow up, 4 patients required repeat pericardiocentesis and pericardiectomy was performed in 0 patients. In the multivariate analysis, patients with large amounts of pericardial effusion (P = .003), those with hypoalbuminemia (P = .011), and those without cardiovascular disease (P = .011) were found to have a higher risk of unfavorable outcomes. Conclusion: HIV-uninfected patients with TB pericarditis are at a higher risk for unfavorable outcomes when presenting with low serum albumin, with large pericardial effusions, and without cardiovascular disease.

AB - Background: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country. Methods: A retrospective review of 87 cases of TB pericarditis diagnosed at a tertiary referral hospital in South Korea was performed. Clinical characteristics, treatment outcomes, complications during treatment, duration of treatment, and medication history were reviewed. Unfavorable outcome was defined as constrictive pericarditis identified on echocardiography performed 3 to 6 months after initial diagnosis of TB pericarditis, cardiac tamponade requiring emergency pericardiocentesis, or death. Predictive factors for unfavorable outcomes were identified. Results: Of the 87 patients, 44 (50.6%) had unfavorable outcomes; cardiac tamponade (n = 36), constrictive pericarditis (n = 18), and mortality (n = 4). 14 patients experienced both cardiac tamponade and constrictive pericarditis. During a 1 year out-patient clinic follow up, 4 patients required repeat pericardiocentesis and pericardiectomy was performed in 0 patients. In the multivariate analysis, patients with large amounts of pericardial effusion (P = .003), those with hypoalbuminemia (P = .011), and those without cardiovascular disease (P = .011) were found to have a higher risk of unfavorable outcomes. Conclusion: HIV-uninfected patients with TB pericarditis are at a higher risk for unfavorable outcomes when presenting with low serum albumin, with large pericardial effusions, and without cardiovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=84999277927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84999277927&partnerID=8YFLogxK

U2 - 10.1186/s12879-016-2062-5

DO - 10.1186/s12879-016-2062-5

M3 - Article

C2 - 27899066

AN - SCOPUS:84999277927

VL - 16

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

IS - 1

M1 - 719

ER -