Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma

Ji Hee Kim, Hyun Ho Jung, Jong Hee Chang, JinWoo Chang, Yong Gou Park, Won Seok Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Gamma Knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications. Methods We undertook a retrospective review of all VS patients treated with the Perfexion Leksell Gamma Knife between November 2007 and October 2010 at our institution. Patients who underwent at least 12 months of clinical and radiologic assessments before and after GKS were included. Results All 235 patients were included in the analyses reported here. The 5-year serviceable hearing and facial nerve preservation values were 73.9% and 94.3%, respectively. Following GKS, 43 patients (18.30%) showed pseudoprogression, 15 (6.38%) exhibited hydrocephalus, 22 (9.36%) showed trigeminal neuropathy, 14 (5.96%) showed vertigo, and 25 (10.64%) showed facial myokymia. According to multivariate analysis, solid tumor nature was significantly associated with pseudoprogression and patient age was significantly associated with hydrocephalus. Patients receiving margin doses ≥13 Gy had a significantly higher probability of loss of serviceable hearing. Patients with smaller tumors had a trigeminal nerve preservation rate comparable with patients harboring larger tumors. Patients receiving margin doses <13 Gy or older patients had a significantly higher probability of vestibular nerve dysfunction. Conclusions Further prospective studies should be designed to provide further insight into the exact relationship between the predictive factors we investigated and post-treatment complications.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalWorld Neurosurgery
Volume107
DOIs
Publication statusPublished - 2017 Nov 1

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Acoustic Neuroma
Radiosurgery
Hydrocephalus
Facial Nerve
Facial Nerve Diseases
Trigeminal Nerve Diseases
Auditory Perception
Vestibular Nerve
Cranial Nerve Diseases
Neoplasms
Trigeminal Nerve
Vertigo
Therapeutics
Hearing Loss
Hearing
Multivariate Analysis
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Kim, Ji Hee ; Jung, Hyun Ho ; Chang, Jong Hee ; Chang, JinWoo ; Park, Yong Gou ; Chang, Won Seok. / Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma. In: World Neurosurgery. 2017 ; Vol. 107. pp. 175-184.
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abstract = "Objective Gamma Knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications. Methods We undertook a retrospective review of all VS patients treated with the Perfexion Leksell Gamma Knife between November 2007 and October 2010 at our institution. Patients who underwent at least 12 months of clinical and radiologic assessments before and after GKS were included. Results All 235 patients were included in the analyses reported here. The 5-year serviceable hearing and facial nerve preservation values were 73.9{\%} and 94.3{\%}, respectively. Following GKS, 43 patients (18.30{\%}) showed pseudoprogression, 15 (6.38{\%}) exhibited hydrocephalus, 22 (9.36{\%}) showed trigeminal neuropathy, 14 (5.96{\%}) showed vertigo, and 25 (10.64{\%}) showed facial myokymia. According to multivariate analysis, solid tumor nature was significantly associated with pseudoprogression and patient age was significantly associated with hydrocephalus. Patients receiving margin doses ≥13 Gy had a significantly higher probability of loss of serviceable hearing. Patients with smaller tumors had a trigeminal nerve preservation rate comparable with patients harboring larger tumors. Patients receiving margin doses <13 Gy or older patients had a significantly higher probability of vestibular nerve dysfunction. Conclusions Further prospective studies should be designed to provide further insight into the exact relationship between the predictive factors we investigated and post-treatment complications.",
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Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma. / Kim, Ji Hee; Jung, Hyun Ho; Chang, Jong Hee; Chang, JinWoo; Park, Yong Gou; Chang, Won Seok.

In: World Neurosurgery, Vol. 107, 01.11.2017, p. 175-184.

Research output: Contribution to journalArticle

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