Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B

JaSeung Koo, Haeryoung Kim, Byung Kyu Park, SangHoon Ahn, KwangHyub Han, Chae Yoon Chon, Chanil Park, Young Nyun Park

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Abstract

GOALS: We aimed to determine whether the presence of large liver cell dysplasia (LLCD) and/or small LCD (SLCD) in chronic hepatitis B is a risk factor for hepatocellular carcinoma (HCC) development. BACKGROUND: A close relationship between LLCD/SLCD and hepatitis B virus has been observed and SLCD has been proposed to be a putative precursor of HCC, whereas the significance of LLCD is still controversial. STUDY: One hundred eighty-one patients with chronic hepatitis B who underwent needle liver biopsy were evaluated for the presence of LLCD/SLCD. The predictive value of LLCD/SLCD for HCC development was assessed. RESULTS: LLCD and SLCD were present at initial biopsy in 82 (45%) and 17 (9%) patients, respectively. During the mean follow-up of 115±48 months, 19 (10%) cases were diagnosed of HCC, of which 13 (76%) and 3 (17%) cases had demonstrated LLCD and SLCD, respectively, at initial evaluation. The patients with LLCD showed a significantly higher cumulative probability of HCC development than those without LLCD (P=0.016). The risk of HCC development in the presence of LLCD was approximately 3-fold, with positive and negative predictive values of 15.9% and 94.9%, respectively. The patients with SLCD showed no significant difference in cumulative probability of HCC development compared with those without (P>0.05). CONCLUSIONS: LLCD in chronic hepatitis B is considered to be one of the risk factors for HCC development and its presence may help to identify a high-risk subgroup of patients requiring more intensive screening for HCC.

Original languageEnglish
Pages (from-to)738-743
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume42
Issue number6
DOIs
Publication statusPublished - 2008 Jul 1

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Chronic Hepatitis B
Hepatocellular Carcinoma
Liver
Needle Biopsy
Hepatitis B virus

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

@article{98c47308c976446c8f9d210da381514f,
title = "Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B",
abstract = "GOALS: We aimed to determine whether the presence of large liver cell dysplasia (LLCD) and/or small LCD (SLCD) in chronic hepatitis B is a risk factor for hepatocellular carcinoma (HCC) development. BACKGROUND: A close relationship between LLCD/SLCD and hepatitis B virus has been observed and SLCD has been proposed to be a putative precursor of HCC, whereas the significance of LLCD is still controversial. STUDY: One hundred eighty-one patients with chronic hepatitis B who underwent needle liver biopsy were evaluated for the presence of LLCD/SLCD. The predictive value of LLCD/SLCD for HCC development was assessed. RESULTS: LLCD and SLCD were present at initial biopsy in 82 (45{\%}) and 17 (9{\%}) patients, respectively. During the mean follow-up of 115±48 months, 19 (10{\%}) cases were diagnosed of HCC, of which 13 (76{\%}) and 3 (17{\%}) cases had demonstrated LLCD and SLCD, respectively, at initial evaluation. The patients with LLCD showed a significantly higher cumulative probability of HCC development than those without LLCD (P=0.016). The risk of HCC development in the presence of LLCD was approximately 3-fold, with positive and negative predictive values of 15.9{\%} and 94.9{\%}, respectively. The patients with SLCD showed no significant difference in cumulative probability of HCC development compared with those without (P>0.05). CONCLUSIONS: LLCD in chronic hepatitis B is considered to be one of the risk factors for HCC development and its presence may help to identify a high-risk subgroup of patients requiring more intensive screening for HCC.",
author = "JaSeung Koo and Haeryoung Kim and Park, {Byung Kyu} and SangHoon Ahn and KwangHyub Han and Chon, {Chae Yoon} and Chanil Park and Park, {Young Nyun}",
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Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B. / Koo, JaSeung; Kim, Haeryoung; Park, Byung Kyu; Ahn, SangHoon; Han, KwangHyub; Chon, Chae Yoon; Park, Chanil; Park, Young Nyun.

In: Journal of Clinical Gastroenterology, Vol. 42, No. 6, 01.07.2008, p. 738-743.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B

AU - Koo, JaSeung

AU - Kim, Haeryoung

AU - Park, Byung Kyu

AU - Ahn, SangHoon

AU - Han, KwangHyub

AU - Chon, Chae Yoon

AU - Park, Chanil

AU - Park, Young Nyun

PY - 2008/7/1

Y1 - 2008/7/1

N2 - GOALS: We aimed to determine whether the presence of large liver cell dysplasia (LLCD) and/or small LCD (SLCD) in chronic hepatitis B is a risk factor for hepatocellular carcinoma (HCC) development. BACKGROUND: A close relationship between LLCD/SLCD and hepatitis B virus has been observed and SLCD has been proposed to be a putative precursor of HCC, whereas the significance of LLCD is still controversial. STUDY: One hundred eighty-one patients with chronic hepatitis B who underwent needle liver biopsy were evaluated for the presence of LLCD/SLCD. The predictive value of LLCD/SLCD for HCC development was assessed. RESULTS: LLCD and SLCD were present at initial biopsy in 82 (45%) and 17 (9%) patients, respectively. During the mean follow-up of 115±48 months, 19 (10%) cases were diagnosed of HCC, of which 13 (76%) and 3 (17%) cases had demonstrated LLCD and SLCD, respectively, at initial evaluation. The patients with LLCD showed a significantly higher cumulative probability of HCC development than those without LLCD (P=0.016). The risk of HCC development in the presence of LLCD was approximately 3-fold, with positive and negative predictive values of 15.9% and 94.9%, respectively. The patients with SLCD showed no significant difference in cumulative probability of HCC development compared with those without (P>0.05). CONCLUSIONS: LLCD in chronic hepatitis B is considered to be one of the risk factors for HCC development and its presence may help to identify a high-risk subgroup of patients requiring more intensive screening for HCC.

AB - GOALS: We aimed to determine whether the presence of large liver cell dysplasia (LLCD) and/or small LCD (SLCD) in chronic hepatitis B is a risk factor for hepatocellular carcinoma (HCC) development. BACKGROUND: A close relationship between LLCD/SLCD and hepatitis B virus has been observed and SLCD has been proposed to be a putative precursor of HCC, whereas the significance of LLCD is still controversial. STUDY: One hundred eighty-one patients with chronic hepatitis B who underwent needle liver biopsy were evaluated for the presence of LLCD/SLCD. The predictive value of LLCD/SLCD for HCC development was assessed. RESULTS: LLCD and SLCD were present at initial biopsy in 82 (45%) and 17 (9%) patients, respectively. During the mean follow-up of 115±48 months, 19 (10%) cases were diagnosed of HCC, of which 13 (76%) and 3 (17%) cases had demonstrated LLCD and SLCD, respectively, at initial evaluation. The patients with LLCD showed a significantly higher cumulative probability of HCC development than those without LLCD (P=0.016). The risk of HCC development in the presence of LLCD was approximately 3-fold, with positive and negative predictive values of 15.9% and 94.9%, respectively. The patients with SLCD showed no significant difference in cumulative probability of HCC development compared with those without (P>0.05). CONCLUSIONS: LLCD in chronic hepatitis B is considered to be one of the risk factors for HCC development and its presence may help to identify a high-risk subgroup of patients requiring more intensive screening for HCC.

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