Predictive value of mesangial C3 and C4d deposition in IgA nephropathy

on behalf of The Korean GlomeruloNEphritis sTudy (KoGNET) Group

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Abstract

We aimed to determine the relative contribution of each complement (C3 and C4d) deposition to the progression of IgA nephropathy (IgAN). We enrolled a total of 380 patients with biopsy-confirmed IgAN. Mesangial deposition of C3(<2+ vs. ≥2+) and C4d(positive vs. negative) was evaluated by immunofluorescence staining and immunohistochemistry, respectively. Study endpoint was the composite of a 30% decline in eGFR or ESRD. The risk of reaching the primary outcome was significantly higher in patients having C3 ≥ 2+ and C4d(+) than in corresponding counterparts. Adding C3 deposition to clinical data acquired at kidney biopsy modestly increased the area under the receiver-operating characteristic curve, net reclassification improvement, and integrated discrimination improvement (IDI); adding C4d increased IDI only. In conclusion, mesangial C3 and C4d deposition was an independent risk factor for progression of IgAN. C3 showed better predictability than C4d, suggesting that lectin pathway alone has limited clinical prognostic value.

Original languageEnglish
Article number108331
JournalClinical Immunology
Volume211
DOIs
Publication statusPublished - 2020 Feb

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    on behalf of The Korean GlomeruloNEphritis sTudy (KoGNET) Group (2020). Predictive value of mesangial C3 and C4d deposition in IgA nephropathy. Clinical Immunology, 211, [108331]. https://doi.org/10.1016/j.clim.2019.108331