Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma

Sung Im Do, Hyun Soo Kim, Kyungeun Kim, Hyunjoo Lee, In Gu Do, Dong Hoon Kim, Seoung Wan Chae, Jin Hee Sohn

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10 Citations (Scopus)


Background/Aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Materials and Methods: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. Results: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). Conclusion: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.

Original languageEnglish
Pages (from-to)5399-5405
Number of pages7
JournalAnticancer research
Issue number10
Publication statusPublished - 2017 Oct

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Do, S. I., Kim, H. S., Kim, K., Lee, H., Do, I. G., Kim, D. H., Chae, S. W., & Sohn, J. H. (2017). Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma. Anticancer research, 37(10), 5399-5405.