Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma

Sung Im Do, Hyun Soo Kim, Kyungeun Kim, Hyunjoo Lee, In Gu Do, Dong Hoon Kim, Seoung Wan Chae, Jin Hee Sohn

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Background/Aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Materials and Methods: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. Results: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). Conclusion: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.

Original languageEnglish
Pages (from-to)5399-5405
Number of pages7
JournalAnticancer research
Volume37
Issue number10
DOIs
Publication statusPublished - 2017 Oct

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Lymph Nodes
Neoplasms
Neoplasm Metastasis
Biomarkers
Nodular Goiter
Sphingolipids
sphingosine kinase
Papillary Thyroid cancer
Thyroid Neoplasms
Paraffin
Formaldehyde
Thyroid Gland
Cytoplasm
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Do, Sung Im ; Kim, Hyun Soo ; Kim, Kyungeun ; Lee, Hyunjoo ; Do, In Gu ; Kim, Dong Hoon ; Chae, Seoung Wan ; Sohn, Jin Hee. / Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma. In: Anticancer research. 2017 ; Vol. 37, No. 10. pp. 5399-5405.
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title = "Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma",
abstract = "Background/Aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Materials and Methods: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. Results: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9{\%}) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). Conclusion: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.",
author = "Do, {Sung Im} and Kim, {Hyun Soo} and Kyungeun Kim and Hyunjoo Lee and Do, {In Gu} and Kim, {Dong Hoon} and Chae, {Seoung Wan} and Sohn, {Jin Hee}",
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Do, SI, Kim, HS, Kim, K, Lee, H, Do, IG, Kim, DH, Chae, SW & Sohn, JH 2017, 'Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma', Anticancer research, vol. 37, no. 10, pp. 5399-5405. https://doi.org/10.21873/anticanres.11967

Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma. / Do, Sung Im; Kim, Hyun Soo; Kim, Kyungeun; Lee, Hyunjoo; Do, In Gu; Kim, Dong Hoon; Chae, Seoung Wan; Sohn, Jin Hee.

In: Anticancer research, Vol. 37, No. 10, 10.2017, p. 5399-5405.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Predictive value of sphingosine kinase 1 expression in papillary thyroid carcinoma

AU - Do, Sung Im

AU - Kim, Hyun Soo

AU - Kim, Kyungeun

AU - Lee, Hyunjoo

AU - Do, In Gu

AU - Kim, Dong Hoon

AU - Chae, Seoung Wan

AU - Sohn, Jin Hee

PY - 2017/10

Y1 - 2017/10

N2 - Background/Aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Materials and Methods: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. Results: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). Conclusion: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.

AB - Background/Aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Materials and Methods: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. Results: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). Conclusion: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.

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JF - Anticancer Research

SN - 0250-7005

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