Predictors for neoatherosclerosis a retrospective observational study from the optical coherence tomography registry

Taishi Yonetsu, Koji Kato, Soo Joong Kim, Lei Xing, Haibo Jia, Iris McNulty, Hang Lee, Shaosong Zhang, Shiro Uemura, Yangsoo Jang, Soo Jin Kang, Seung Jung Park, Stephen Lee, Bo Yu, Tsunekazu Kakuta, Ik Kyung Jang

Research output: Contribution to journalArticle

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Abstract

Background-Recent studies have reported development of neoatherosclerosis (NA) inside the stents several years after stent implantation. The aim of this study was to determine the predictors for NA using optical coherence tomography. Methods and Results-From a total of 1080 patients who underwent optical coherence tomography, we identified 179 stents in 151 patients in which the mean neointimal thickness was >100 ?m. The presence of lipid-laden neointima or calcification inside the stents was defined as NA in the present study. Patient characteristics, stent type, and time since stent implantation (stent age) were compared between stents with or without NA. Univariable and multivariable logistic regression analyses were used to assess the independent predictors. In univariate analysis, stent age ≫48 months (Odds ratio [OR], 4.48; [95% CI 2.68-9.65]; P <0.001), drug-eluting stents (OR, 2.66; [95% CI, 1.38-5.16]; P=0.004), age ≫65 years (OR, 1.91; [95% CI, 1.05-3.44]; P=0.032), current smoking (OR, 2.30; [95% CI, 1.10-4.82]; P=0.024), chronic kidney disease (OR, 4.17; [95% CI, 1.42-12.23]; P=0.009), and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockade use (OR, 0.42; [95% CI, 0.22-0.80]; P=0.008) were significant predictors. In multivariate analysis, stent age ≫48 months, all subtypes of drug-eluting stent, current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade use remained independent predictors for NA. Conclusions-In addition to the stent type and the stent age, patient characteristics, including current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade, were associated with the presence of NA. This result may support the importance of secondary prevention after stent implantation.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalCirculation: Cardiovascular Imaging
Volume5
Issue number5
DOIs
Publication statusPublished - 2012 Oct 11

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Optical Coherence Tomography
Stents
Observational Studies
Registries
Retrospective Studies
Odds Ratio
Angiotensin Receptors
Chronic Renal Insufficiency
Angiotensin-Converting Enzyme Inhibitors
Drug-Eluting Stents
Smoking
Neointima
Secondary Prevention
Multivariate Analysis
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Yonetsu, Taishi ; Kato, Koji ; Kim, Soo Joong ; Xing, Lei ; Jia, Haibo ; McNulty, Iris ; Lee, Hang ; Zhang, Shaosong ; Uemura, Shiro ; Jang, Yangsoo ; Kang, Soo Jin ; Park, Seung Jung ; Lee, Stephen ; Yu, Bo ; Kakuta, Tsunekazu ; Jang, Ik Kyung. / Predictors for neoatherosclerosis a retrospective observational study from the optical coherence tomography registry. In: Circulation: Cardiovascular Imaging. 2012 ; Vol. 5, No. 5. pp. 660-666.
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abstract = "Background-Recent studies have reported development of neoatherosclerosis (NA) inside the stents several years after stent implantation. The aim of this study was to determine the predictors for NA using optical coherence tomography. Methods and Results-From a total of 1080 patients who underwent optical coherence tomography, we identified 179 stents in 151 patients in which the mean neointimal thickness was >100 ?m. The presence of lipid-laden neointima or calcification inside the stents was defined as NA in the present study. Patient characteristics, stent type, and time since stent implantation (stent age) were compared between stents with or without NA. Univariable and multivariable logistic regression analyses were used to assess the independent predictors. In univariate analysis, stent age ≫48 months (Odds ratio [OR], 4.48; [95{\%} CI 2.68-9.65]; P <0.001), drug-eluting stents (OR, 2.66; [95{\%} CI, 1.38-5.16]; P=0.004), age ≫65 years (OR, 1.91; [95{\%} CI, 1.05-3.44]; P=0.032), current smoking (OR, 2.30; [95{\%} CI, 1.10-4.82]; P=0.024), chronic kidney disease (OR, 4.17; [95{\%} CI, 1.42-12.23]; P=0.009), and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockade use (OR, 0.42; [95{\%} CI, 0.22-0.80]; P=0.008) were significant predictors. In multivariate analysis, stent age ≫48 months, all subtypes of drug-eluting stent, current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade use remained independent predictors for NA. Conclusions-In addition to the stent type and the stent age, patient characteristics, including current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade, were associated with the presence of NA. This result may support the importance of secondary prevention after stent implantation.",
author = "Taishi Yonetsu and Koji Kato and Kim, {Soo Joong} and Lei Xing and Haibo Jia and Iris McNulty and Hang Lee and Shaosong Zhang and Shiro Uemura and Yangsoo Jang and Kang, {Soo Jin} and Park, {Seung Jung} and Stephen Lee and Bo Yu and Tsunekazu Kakuta and Jang, {Ik Kyung}",
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Yonetsu, T, Kato, K, Kim, SJ, Xing, L, Jia, H, McNulty, I, Lee, H, Zhang, S, Uemura, S, Jang, Y, Kang, SJ, Park, SJ, Lee, S, Yu, B, Kakuta, T & Jang, IK 2012, 'Predictors for neoatherosclerosis a retrospective observational study from the optical coherence tomography registry', Circulation: Cardiovascular Imaging, vol. 5, no. 5, pp. 660-666. https://doi.org/10.1161/CIRCIMAGING.112.976167

Predictors for neoatherosclerosis a retrospective observational study from the optical coherence tomography registry. / Yonetsu, Taishi; Kato, Koji; Kim, Soo Joong; Xing, Lei; Jia, Haibo; McNulty, Iris; Lee, Hang; Zhang, Shaosong; Uemura, Shiro; Jang, Yangsoo; Kang, Soo Jin; Park, Seung Jung; Lee, Stephen; Yu, Bo; Kakuta, Tsunekazu; Jang, Ik Kyung.

In: Circulation: Cardiovascular Imaging, Vol. 5, No. 5, 11.10.2012, p. 660-666.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictors for neoatherosclerosis a retrospective observational study from the optical coherence tomography registry

AU - Yonetsu, Taishi

AU - Kato, Koji

AU - Kim, Soo Joong

AU - Xing, Lei

AU - Jia, Haibo

AU - McNulty, Iris

AU - Lee, Hang

AU - Zhang, Shaosong

AU - Uemura, Shiro

AU - Jang, Yangsoo

AU - Kang, Soo Jin

AU - Park, Seung Jung

AU - Lee, Stephen

AU - Yu, Bo

AU - Kakuta, Tsunekazu

AU - Jang, Ik Kyung

PY - 2012/10/11

Y1 - 2012/10/11

N2 - Background-Recent studies have reported development of neoatherosclerosis (NA) inside the stents several years after stent implantation. The aim of this study was to determine the predictors for NA using optical coherence tomography. Methods and Results-From a total of 1080 patients who underwent optical coherence tomography, we identified 179 stents in 151 patients in which the mean neointimal thickness was >100 ?m. The presence of lipid-laden neointima or calcification inside the stents was defined as NA in the present study. Patient characteristics, stent type, and time since stent implantation (stent age) were compared between stents with or without NA. Univariable and multivariable logistic regression analyses were used to assess the independent predictors. In univariate analysis, stent age ≫48 months (Odds ratio [OR], 4.48; [95% CI 2.68-9.65]; P <0.001), drug-eluting stents (OR, 2.66; [95% CI, 1.38-5.16]; P=0.004), age ≫65 years (OR, 1.91; [95% CI, 1.05-3.44]; P=0.032), current smoking (OR, 2.30; [95% CI, 1.10-4.82]; P=0.024), chronic kidney disease (OR, 4.17; [95% CI, 1.42-12.23]; P=0.009), and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockade use (OR, 0.42; [95% CI, 0.22-0.80]; P=0.008) were significant predictors. In multivariate analysis, stent age ≫48 months, all subtypes of drug-eluting stent, current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade use remained independent predictors for NA. Conclusions-In addition to the stent type and the stent age, patient characteristics, including current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade, were associated with the presence of NA. This result may support the importance of secondary prevention after stent implantation.

AB - Background-Recent studies have reported development of neoatherosclerosis (NA) inside the stents several years after stent implantation. The aim of this study was to determine the predictors for NA using optical coherence tomography. Methods and Results-From a total of 1080 patients who underwent optical coherence tomography, we identified 179 stents in 151 patients in which the mean neointimal thickness was >100 ?m. The presence of lipid-laden neointima or calcification inside the stents was defined as NA in the present study. Patient characteristics, stent type, and time since stent implantation (stent age) were compared between stents with or without NA. Univariable and multivariable logistic regression analyses were used to assess the independent predictors. In univariate analysis, stent age ≫48 months (Odds ratio [OR], 4.48; [95% CI 2.68-9.65]; P <0.001), drug-eluting stents (OR, 2.66; [95% CI, 1.38-5.16]; P=0.004), age ≫65 years (OR, 1.91; [95% CI, 1.05-3.44]; P=0.032), current smoking (OR, 2.30; [95% CI, 1.10-4.82]; P=0.024), chronic kidney disease (OR, 4.17; [95% CI, 1.42-12.23]; P=0.009), and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockade use (OR, 0.42; [95% CI, 0.22-0.80]; P=0.008) were significant predictors. In multivariate analysis, stent age ≫48 months, all subtypes of drug-eluting stent, current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade use remained independent predictors for NA. Conclusions-In addition to the stent type and the stent age, patient characteristics, including current smoking, chronic kidney disease, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockade, were associated with the presence of NA. This result may support the importance of secondary prevention after stent implantation.

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