Predictors of asthma control by stepwise treatment in elderly asthmatic patients

Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group

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Abstract

The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of = 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients.

Original languageEnglish
Pages (from-to)1042-1047
Number of pages6
JournalJournal of Korean medical science
Volume30
Issue number8
DOIs
Publication statusPublished - 2015 Jan 1

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Asthma
Therapeutics
Control Groups
Comorbidity
Quality of Life
Korea
Geriatrics
Guidelines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group (2015). Predictors of asthma control by stepwise treatment in elderly asthmatic patients. Journal of Korean medical science, 30(8), 1042-1047. https://doi.org/10.3346/jkms.2015.30.8.1042
Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group. / Predictors of asthma control by stepwise treatment in elderly asthmatic patients. In: Journal of Korean medical science. 2015 ; Vol. 30, No. 8. pp. 1042-1047.
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abstract = "The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of = 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients.",
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Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group 2015, 'Predictors of asthma control by stepwise treatment in elderly asthmatic patients', Journal of Korean medical science, vol. 30, no. 8, pp. 1042-1047. https://doi.org/10.3346/jkms.2015.30.8.1042

Predictors of asthma control by stepwise treatment in elderly asthmatic patients. / Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group.

In: Journal of Korean medical science, Vol. 30, No. 8, 01.01.2015, p. 1042-1047.

Research output: Contribution to journalArticle

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AU - Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group

AU - Ban, Ga Young

AU - Ye, Young Min

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AU - Kim, Jeong Eun

AU - Nam, Young Hee

AU - Lee, Soo Keol

AU - Kim, Joo Hee

AU - Jung, Ki Suck

AU - Kim, Sangha

AU - Park, Hae Sim

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Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group. Predictors of asthma control by stepwise treatment in elderly asthmatic patients. Journal of Korean medical science. 2015 Jan 1;30(8):1042-1047. https://doi.org/10.3346/jkms.2015.30.8.1042