TY - JOUR
T1 - Predictors of diffuse-type in-stent restenosis after coronary stent implantation
AU - Lee, Sang Gon
AU - Lee, Cheol Whan
AU - Hong, Myeong Ki
AU - Park, Hoon Ki
AU - Kim, Jae Joong
AU - Park, Seong Wook
AU - Park, Seung Jung
PY - 1999/8
Y1 - 1999/8
N2 - Diffuse-type in-stent restenosis (ISR) is associated with higher rate of restenosis after balloon angioplasty, requiring new therapeutic modalities; therefore, it is clinically important to identify the determinants of diffuse-type ISR. We evaluate the clinical and angiographic variables to predict diffuse-type ISR after coronary stent placement. Two hundred and ten ISR lesions in 196 patients (diffuse ISR, 114 lesions; focal ISR, 96 lesions) were reviewed in this study. Clinical, procedural and quantitative coronary angiographic parameters were analyzed. Diffuse-type ISR was defined as a ≥50% lumen narrowing and ≥10-mm length. Univariate analysis revealed that initial lesion length, smaller vessel size, diabetes, multivessel disease, multiple stents, and long stent were significantly associated with diffuse- type ISR. However, diabetes was the only independent predictor of diffuse- type ISR by stepwise multiple regression analysis (OR, 3.3; 95% CI, 1.4-7.4, P = 0.001). Diabetes was associated with diffuse-type ISR after coronary stent placement. It may reflect enhanced rate of neointimal hyperplasia within the stent in diabetic patients.
AB - Diffuse-type in-stent restenosis (ISR) is associated with higher rate of restenosis after balloon angioplasty, requiring new therapeutic modalities; therefore, it is clinically important to identify the determinants of diffuse-type ISR. We evaluate the clinical and angiographic variables to predict diffuse-type ISR after coronary stent placement. Two hundred and ten ISR lesions in 196 patients (diffuse ISR, 114 lesions; focal ISR, 96 lesions) were reviewed in this study. Clinical, procedural and quantitative coronary angiographic parameters were analyzed. Diffuse-type ISR was defined as a ≥50% lumen narrowing and ≥10-mm length. Univariate analysis revealed that initial lesion length, smaller vessel size, diabetes, multivessel disease, multiple stents, and long stent were significantly associated with diffuse- type ISR. However, diabetes was the only independent predictor of diffuse- type ISR by stepwise multiple regression analysis (OR, 3.3; 95% CI, 1.4-7.4, P = 0.001). Diabetes was associated with diffuse-type ISR after coronary stent placement. It may reflect enhanced rate of neointimal hyperplasia within the stent in diabetic patients.
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U2 - 10.1002/(SICI)1522-726X(199908)47:4<406::AID-CCD5>3.0.CO;2-P
DO - 10.1002/(SICI)1522-726X(199908)47:4<406::AID-CCD5>3.0.CO;2-P
M3 - Article
C2 - 10470468
AN - SCOPUS:0032795306
VL - 47
SP - 406
EP - 409
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
IS - 4
ER -