Predictors of diffuse-type in-stent restenosis after coronary stent implantation

Sang Gon Lee, Cheol Whan Lee, Myeong Ki Hong, Hoon Ki Park, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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28 Citations (Scopus)


Diffuse-type in-stent restenosis (ISR) is associated with higher rate of restenosis after balloon angioplasty, requiring new therapeutic modalities; therefore, it is clinically important to identify the determinants of diffuse-type ISR. We evaluate the clinical and angiographic variables to predict diffuse-type ISR after coronary stent placement. Two hundred and ten ISR lesions in 196 patients (diffuse ISR, 114 lesions; focal ISR, 96 lesions) were reviewed in this study. Clinical, procedural and quantitative coronary angiographic parameters were analyzed. Diffuse-type ISR was defined as a ≥50% lumen narrowing and ≥10-mm length. Univariate analysis revealed that initial lesion length, smaller vessel size, diabetes, multivessel disease, multiple stents, and long stent were significantly associated with diffuse- type ISR. However, diabetes was the only independent predictor of diffuse- type ISR by stepwise multiple regression analysis (OR, 3.3; 95% CI, 1.4-7.4, P = 0.001). Diabetes was associated with diffuse-type ISR after coronary stent placement. It may reflect enhanced rate of neointimal hyperplasia within the stent in diabetic patients.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalCatheterization and Cardiovascular Interventions
Issue number4
Publication statusPublished - 1999 Aug

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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