Predictors of long-term survival in pN3 gastric cancer patients

Junuk Kim, Ho Cheong Jae, Jin Hyung Woo, Jianguo Shen, Ho Choi Seung, Hoon Noh Sung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Objectives: Patients with pN3 gastric cancer are classified as having a stage IV disease just by virtue of having more than 15 metastatic lymph nodes according to the 5th UICC cancer staging criteria. We tried to verify whether the pN3 gastric cancer patients truly constitute a homogeneous group with the same poor prognosis by looking for predictors of long-term survival within the group. Methods: Medical records of 347 patients who had gastrectomy with D2/D3 lymph node dissection for gastric cancer and diagnosed with pN3 disease by pathology, between January 1987 and December 1997 were reviewed. Clinicopathologic prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Results: The overall 5-year survival rate was 13.0% (95% CI, 9.3-16.6%). The extent of gastric resection and metastatic lymph node ratio were significant independent predictors of long-term survival on multivariate analysis. The 5-year survival rates for the subtotal and total gastrectomy groups were 18.2 and 8.8%, respectively. The 5-year survival rate according to the metastatic lymph node ratio was 20.2, 8.9, and 1.9% when the ratio was <0.33, 0.33-0.67, and >0.67, respectively. Conclusions: Patients with pN3 gastric cancer appear to be a heterogeneous group with clinicopathologic predictors that identify subgroups with significantly different long-term prognoses. The metastatic lymph node ratio may serve as a valuable tool to predict the long-term prognosis of these patients.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Surgical Oncology
Volume88
Issue number1
DOIs
Publication statusPublished - 2004 Oct 1

Fingerprint

Stomach Neoplasms
Lymph Nodes
Survival
Survival Rate
Gastrectomy
Multivariate Analysis
Neoplasm Staging
Survival Analysis
Lymph Node Excision
Medical Records
Stomach
Pathology

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Junuk ; Jae, Ho Cheong ; Woo, Jin Hyung ; Shen, Jianguo ; Seung, Ho Choi ; Sung, Hoon Noh. / Predictors of long-term survival in pN3 gastric cancer patients. In: Journal of Surgical Oncology. 2004 ; Vol. 88, No. 1. pp. 9-13.
@article{6709169412c244c388cf51f2b35ee389,
title = "Predictors of long-term survival in pN3 gastric cancer patients",
abstract = "Background and Objectives: Patients with pN3 gastric cancer are classified as having a stage IV disease just by virtue of having more than 15 metastatic lymph nodes according to the 5th UICC cancer staging criteria. We tried to verify whether the pN3 gastric cancer patients truly constitute a homogeneous group with the same poor prognosis by looking for predictors of long-term survival within the group. Methods: Medical records of 347 patients who had gastrectomy with D2/D3 lymph node dissection for gastric cancer and diagnosed with pN3 disease by pathology, between January 1987 and December 1997 were reviewed. Clinicopathologic prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Results: The overall 5-year survival rate was 13.0{\%} (95{\%} CI, 9.3-16.6{\%}). The extent of gastric resection and metastatic lymph node ratio were significant independent predictors of long-term survival on multivariate analysis. The 5-year survival rates for the subtotal and total gastrectomy groups were 18.2 and 8.8{\%}, respectively. The 5-year survival rate according to the metastatic lymph node ratio was 20.2, 8.9, and 1.9{\%} when the ratio was <0.33, 0.33-0.67, and >0.67, respectively. Conclusions: Patients with pN3 gastric cancer appear to be a heterogeneous group with clinicopathologic predictors that identify subgroups with significantly different long-term prognoses. The metastatic lymph node ratio may serve as a valuable tool to predict the long-term prognosis of these patients.",
author = "Junuk Kim and Jae, {Ho Cheong} and Woo, {Jin Hyung} and Jianguo Shen and Seung, {Ho Choi} and Sung, {Hoon Noh}",
year = "2004",
month = "10",
day = "1",
doi = "10.1002/jso.20130",
language = "English",
volume = "88",
pages = "9--13",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "1",

}

Predictors of long-term survival in pN3 gastric cancer patients. / Kim, Junuk; Jae, Ho Cheong; Woo, Jin Hyung; Shen, Jianguo; Seung, Ho Choi; Sung, Hoon Noh.

In: Journal of Surgical Oncology, Vol. 88, No. 1, 01.10.2004, p. 9-13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictors of long-term survival in pN3 gastric cancer patients

AU - Kim, Junuk

AU - Jae, Ho Cheong

AU - Woo, Jin Hyung

AU - Shen, Jianguo

AU - Seung, Ho Choi

AU - Sung, Hoon Noh

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Background and Objectives: Patients with pN3 gastric cancer are classified as having a stage IV disease just by virtue of having more than 15 metastatic lymph nodes according to the 5th UICC cancer staging criteria. We tried to verify whether the pN3 gastric cancer patients truly constitute a homogeneous group with the same poor prognosis by looking for predictors of long-term survival within the group. Methods: Medical records of 347 patients who had gastrectomy with D2/D3 lymph node dissection for gastric cancer and diagnosed with pN3 disease by pathology, between January 1987 and December 1997 were reviewed. Clinicopathologic prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Results: The overall 5-year survival rate was 13.0% (95% CI, 9.3-16.6%). The extent of gastric resection and metastatic lymph node ratio were significant independent predictors of long-term survival on multivariate analysis. The 5-year survival rates for the subtotal and total gastrectomy groups were 18.2 and 8.8%, respectively. The 5-year survival rate according to the metastatic lymph node ratio was 20.2, 8.9, and 1.9% when the ratio was <0.33, 0.33-0.67, and >0.67, respectively. Conclusions: Patients with pN3 gastric cancer appear to be a heterogeneous group with clinicopathologic predictors that identify subgroups with significantly different long-term prognoses. The metastatic lymph node ratio may serve as a valuable tool to predict the long-term prognosis of these patients.

AB - Background and Objectives: Patients with pN3 gastric cancer are classified as having a stage IV disease just by virtue of having more than 15 metastatic lymph nodes according to the 5th UICC cancer staging criteria. We tried to verify whether the pN3 gastric cancer patients truly constitute a homogeneous group with the same poor prognosis by looking for predictors of long-term survival within the group. Methods: Medical records of 347 patients who had gastrectomy with D2/D3 lymph node dissection for gastric cancer and diagnosed with pN3 disease by pathology, between January 1987 and December 1997 were reviewed. Clinicopathologic prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Results: The overall 5-year survival rate was 13.0% (95% CI, 9.3-16.6%). The extent of gastric resection and metastatic lymph node ratio were significant independent predictors of long-term survival on multivariate analysis. The 5-year survival rates for the subtotal and total gastrectomy groups were 18.2 and 8.8%, respectively. The 5-year survival rate according to the metastatic lymph node ratio was 20.2, 8.9, and 1.9% when the ratio was <0.33, 0.33-0.67, and >0.67, respectively. Conclusions: Patients with pN3 gastric cancer appear to be a heterogeneous group with clinicopathologic predictors that identify subgroups with significantly different long-term prognoses. The metastatic lymph node ratio may serve as a valuable tool to predict the long-term prognosis of these patients.

UR - http://www.scopus.com/inward/record.url?scp=4744363345&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4744363345&partnerID=8YFLogxK

U2 - 10.1002/jso.20130

DO - 10.1002/jso.20130

M3 - Article

C2 - 15384089

AN - SCOPUS:4744363345

VL - 88

SP - 9

EP - 13

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -