Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia

Hanna Cho, Sang Won Seo, Jae Yong Choi, Hye Sun Lee, Young Hoon Ryu, Myung Sik Lee, Duk L. Na, Hee Jin Kim, Chulhyoung Lyoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Behavioral variant frontotemporal dementia (bvFTD) is the most common form of frontotemporal dementia, and tau pathology can be found in 40%–50% of bvFTD patients. In this study, we sought to investigate 18F-flortaucipir-binding patterns and their correlates in clinically diagnosed bvFTD patients by comparing with results for Alzheimer's disease (AD) patients. We enrolled 20 bvFTD, 20 AD, and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with 18F-flortaucipir. Regional standardized uptake value ratios for the cerebral cortex and underlying white matter were compared between the 2 groups. The bvFTD patients showed increased 18F-flortaucipir binding in the putamen and globus pallidus when compared to the healthy controls. In addition, bvFTD was associated with increased binding in the white matter regions underlying the frontal, anterior cingulate, and insula cortices. The bvFTD patients may exhibit predominantly subcortical 18F-flortaucipir-binding pattern that is distinct from the patterns seen in AD patients. We hypothesize that the clinical characteristics of bvFTD patients may be attributable to the dysfunctional frontal-subcortical networks. However, concerns remain regarding unknown “off-target” binding in the white matter and the basal ganglia.

Original languageEnglish
Pages (from-to)112-121
Number of pages10
JournalNeurobiology of Aging
Volume66
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Frontotemporal Dementia
Alzheimer Disease
Globus Pallidus
Neuropsychological Tests
Putamen
Gyrus Cinguli
Basal Ganglia
Positron-Emission Tomography
Cerebral Cortex
Healthy Volunteers
Magnetic Resonance Imaging
Pathology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Cho, Hanna ; Seo, Sang Won ; Choi, Jae Yong ; Lee, Hye Sun ; Ryu, Young Hoon ; Lee, Myung Sik ; Na, Duk L. ; Kim, Hee Jin ; Lyoo, Chulhyoung. / Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia. In: Neurobiology of Aging. 2018 ; Vol. 66. pp. 112-121.
@article{0370c9017ad94ff1afadbc935cffc66a,
title = "Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia",
abstract = "Behavioral variant frontotemporal dementia (bvFTD) is the most common form of frontotemporal dementia, and tau pathology can be found in 40{\%}–50{\%} of bvFTD patients. In this study, we sought to investigate 18F-flortaucipir-binding patterns and their correlates in clinically diagnosed bvFTD patients by comparing with results for Alzheimer's disease (AD) patients. We enrolled 20 bvFTD, 20 AD, and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with 18F-flortaucipir. Regional standardized uptake value ratios for the cerebral cortex and underlying white matter were compared between the 2 groups. The bvFTD patients showed increased 18F-flortaucipir binding in the putamen and globus pallidus when compared to the healthy controls. In addition, bvFTD was associated with increased binding in the white matter regions underlying the frontal, anterior cingulate, and insula cortices. The bvFTD patients may exhibit predominantly subcortical 18F-flortaucipir-binding pattern that is distinct from the patterns seen in AD patients. We hypothesize that the clinical characteristics of bvFTD patients may be attributable to the dysfunctional frontal-subcortical networks. However, concerns remain regarding unknown “off-target” binding in the white matter and the basal ganglia.",
author = "Hanna Cho and Seo, {Sang Won} and Choi, {Jae Yong} and Lee, {Hye Sun} and Ryu, {Young Hoon} and Lee, {Myung Sik} and Na, {Duk L.} and Kim, {Hee Jin} and Chulhyoung Lyoo",
year = "2018",
month = "6",
day = "1",
doi = "10.1016/j.neurobiolaging.2018.02.015",
language = "English",
volume = "66",
pages = "112--121",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia. / Cho, Hanna; Seo, Sang Won; Choi, Jae Yong; Lee, Hye Sun; Ryu, Young Hoon; Lee, Myung Sik; Na, Duk L.; Kim, Hee Jin; Lyoo, Chulhyoung.

In: Neurobiology of Aging, Vol. 66, 01.06.2018, p. 112-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia

AU - Cho, Hanna

AU - Seo, Sang Won

AU - Choi, Jae Yong

AU - Lee, Hye Sun

AU - Ryu, Young Hoon

AU - Lee, Myung Sik

AU - Na, Duk L.

AU - Kim, Hee Jin

AU - Lyoo, Chulhyoung

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Behavioral variant frontotemporal dementia (bvFTD) is the most common form of frontotemporal dementia, and tau pathology can be found in 40%–50% of bvFTD patients. In this study, we sought to investigate 18F-flortaucipir-binding patterns and their correlates in clinically diagnosed bvFTD patients by comparing with results for Alzheimer's disease (AD) patients. We enrolled 20 bvFTD, 20 AD, and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with 18F-flortaucipir. Regional standardized uptake value ratios for the cerebral cortex and underlying white matter were compared between the 2 groups. The bvFTD patients showed increased 18F-flortaucipir binding in the putamen and globus pallidus when compared to the healthy controls. In addition, bvFTD was associated with increased binding in the white matter regions underlying the frontal, anterior cingulate, and insula cortices. The bvFTD patients may exhibit predominantly subcortical 18F-flortaucipir-binding pattern that is distinct from the patterns seen in AD patients. We hypothesize that the clinical characteristics of bvFTD patients may be attributable to the dysfunctional frontal-subcortical networks. However, concerns remain regarding unknown “off-target” binding in the white matter and the basal ganglia.

AB - Behavioral variant frontotemporal dementia (bvFTD) is the most common form of frontotemporal dementia, and tau pathology can be found in 40%–50% of bvFTD patients. In this study, we sought to investigate 18F-flortaucipir-binding patterns and their correlates in clinically diagnosed bvFTD patients by comparing with results for Alzheimer's disease (AD) patients. We enrolled 20 bvFTD, 20 AD, and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with 18F-flortaucipir. Regional standardized uptake value ratios for the cerebral cortex and underlying white matter were compared between the 2 groups. The bvFTD patients showed increased 18F-flortaucipir binding in the putamen and globus pallidus when compared to the healthy controls. In addition, bvFTD was associated with increased binding in the white matter regions underlying the frontal, anterior cingulate, and insula cortices. The bvFTD patients may exhibit predominantly subcortical 18F-flortaucipir-binding pattern that is distinct from the patterns seen in AD patients. We hypothesize that the clinical characteristics of bvFTD patients may be attributable to the dysfunctional frontal-subcortical networks. However, concerns remain regarding unknown “off-target” binding in the white matter and the basal ganglia.

UR - http://www.scopus.com/inward/record.url?scp=85044003819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044003819&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2018.02.015

DO - 10.1016/j.neurobiolaging.2018.02.015

M3 - Article

C2 - 29554554

AN - SCOPUS:85044003819

VL - 66

SP - 112

EP - 121

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -