Pregabalin reduces post-operative pain after mastectomy: A double-blind, randomized, placebo-controlled study

S. Y. Kim, J. W. Song, B. Park, S. Park, Y. J. An, Y. H. Shim

Research output: Contribution to journalArticle

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Abstract

Background: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post-operative pain. The aim of this randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was to investigate the efficacy and safety of pregabalin for reducing post-operative pain in patients after mastectomy. Methods: Eighty-four women scheduled for elective mastectomy were randomly assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before surgery and 12 h after the initial dose. Assessments of pain [verbal numerical rating scale (VNRS), at rest and with arm abduction] and side effects were performed at 1, 6, 24 and 48 h post-operatively. After discharge from the hospital, pain was assessed by telephone interview at post-operative 1 week and 1 month. Results: VNRS scores for pain at rest were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS scores for pain with arm abduction were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05). Incidences of side effects such as nausea and vomiting, headache, dizziness and blurred vision were similar in both groups. Conclusion: Perioperative administration of pregabalin for a single day (75 mg twice daily) was easy, safe and effective in reducing post-operative pain in patients undergoing mastectomy.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Volume55
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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Mastectomy
Placebos
Pain
Dizziness
Neuralgia
Pain Measurement
Nausea
Vomiting
Headache
Analgesics
Pregabalin
Clinical Trials
Interviews
Safety
Incidence

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Kim, S. Y. ; Song, J. W. ; Park, B. ; Park, S. ; An, Y. J. ; Shim, Y. H. / Pregabalin reduces post-operative pain after mastectomy : A double-blind, randomized, placebo-controlled study. In: Acta Anaesthesiologica Scandinavica. 2011 ; Vol. 55, No. 3. pp. 290-296.
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Pregabalin reduces post-operative pain after mastectomy : A double-blind, randomized, placebo-controlled study. / Kim, S. Y.; Song, J. W.; Park, B.; Park, S.; An, Y. J.; Shim, Y. H.

In: Acta Anaesthesiologica Scandinavica, Vol. 55, No. 3, 01.03.2011, p. 290-296.

Research output: Contribution to journalArticle

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AU - Kim, S. Y.

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AU - An, Y. J.

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N2 - Background: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post-operative pain. The aim of this randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was to investigate the efficacy and safety of pregabalin for reducing post-operative pain in patients after mastectomy. Methods: Eighty-four women scheduled for elective mastectomy were randomly assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before surgery and 12 h after the initial dose. Assessments of pain [verbal numerical rating scale (VNRS), at rest and with arm abduction] and side effects were performed at 1, 6, 24 and 48 h post-operatively. After discharge from the hospital, pain was assessed by telephone interview at post-operative 1 week and 1 month. Results: VNRS scores for pain at rest were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS scores for pain with arm abduction were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05). Incidences of side effects such as nausea and vomiting, headache, dizziness and blurred vision were similar in both groups. Conclusion: Perioperative administration of pregabalin for a single day (75 mg twice daily) was easy, safe and effective in reducing post-operative pain in patients undergoing mastectomy.

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