Pregnancy rates and outcomes of HIV-infected women in Korea

Heun Choi, Moo Hyun Kim, Se Ju Lee, Eun Jin Kim, Woonji Lee, Wooyong Jeong, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Ji Hyeon Baek, Young Hwa Choi, Hyo Youl Kim, June Myung Kim, Jun Yong Choi

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Abstract

Background: Antepartum, intrapartum, and postpartum preventive measures with antiretroviral drugs, appropriate delivery methods, and discouraging breastfeeding significantly decrease the risk of mother-to-child transmission of human immunodeficiency virus (HIV) infection. Herein, we investigated the pregnancy outcomes in HIV-infected Korean women. Methods: We retrospectively reviewed medical records of childbearing-age HIV-infected women between January 2005 and June 2017 at four tertiary care hospitals in Korea. Results: Among a total of 95 HIV infected women of child-bearing age with 587.61 years of follow-up duration, 15 HIV-infected women experienced 21 pregnancies and delivered 16 infants. The pregnancy rate was 3.57 per 100 patient-years. Among the 21 pregnancies, five ended with an induced abortion, and 16 with childbirth including two preterm deliveries at 24 and 35 weeks of gestation, respectively. The two preterm infants had low birth weight and one of them died 10 days after delivery due to respiratory failure. Among the 14 full-term infants, one infant was small for gestational age. There were no HIV-infected infants. Conclusion: The pregnancy rate of HIV-infected women in Korea is lower than that of the general population. Although several adverse pregnancy outcomes were observed, mother-to-child transmission of HIV infection was successfully prevented with effective preventive measures.

Original languageEnglish
Article numbere296
JournalJournal of Korean medical science
Volume33
Issue number47
DOIs
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This work was supported by the BioNano Health-Guard Research Center funded by the Ministry of Science, ICT, and Future Planning of Korea as a Global Frontier Project (grant H-GUARD_2013M3A6B2078953); a grant from the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1324); a faculty research grant of Yonsei University College of Medicine (6-2015-0153); and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2005412)

Publisher Copyright:
© 2018 The Korean Academy of Medical Sciences.

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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