Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity

Nguyen Thi Kim Thuy, Phan Tuan Phuong, Nguyen Thi Mai, Truong Thi Thu Hien, Nguyen Thi Cuc, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Ki Sung Kang, Seung Huyn Kim, Nguyen Xuan Nhiem

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%).

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalPhytochemistry Letters
Publication statusPublished - 2020 Jun

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.99-2017.340 .

Publisher Copyright:
© 2020 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science


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