Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity

Nguyen Thi Kim Thuy; Phan Tuan Phuong; Nguyen Thi Mai; Truong Thi Thu Hien; Nguyen Thi Cuc; Bui Huu Tai; Phan Van Kiem; Chau Van Minh; Ki Sung Kang; Seung Huyn Kim; Nguyen Xuan Nhiem

doi:10.1016/j.phytol.2020.04.013

Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity

Nguyen Thi Kim Thuy, Phan Tuan Phuong, Nguyen Thi Mai, Truong Thi Thu Hien, Nguyen Thi Cuc, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Ki Sung Kang, Seung Huyn Kim, Nguyen Xuan Nhiem

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%).

Original language	English
Pages (from-to)	90-94
Number of pages	5
Journal	Phytochemistry Letters
Volume	37
DOIs	https://doi.org/10.1016/j.phytol.2020.04.013
Publication status	Published - 2020 Jun

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.99-2017.340 .

Publisher Copyright:
© 2020 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2020.04.013

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title = "Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity",

abstract = "Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%).",

author = "Thuy, {Nguyen Thi Kim} and Phuong, {Phan Tuan} and Mai, {Nguyen Thi} and Hien, {Truong Thi Thu} and Cuc, {Nguyen Thi} and Tai, {Bui Huu} and Kiem, {Phan Van} and Minh, {Chau Van} and Kang, {Ki Sung} and Kim, {Seung Huyn} and Nhiem, {Nguyen Xuan}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.99-2017.340 . Publisher Copyright: {\textcopyright} 2020 Phytochemical Society of Europe",

year = "2020",

month = jun,

doi = "10.1016/j.phytol.2020.04.013",

language = "English",

volume = "37",

pages = "90--94",

journal = "Phytochemistry Letters",

issn = "1874-3900",

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TY - JOUR

T1 - Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity

AU - Thuy, Nguyen Thi Kim

AU - Phuong, Phan Tuan

AU - Mai, Nguyen Thi

AU - Hien, Truong Thi Thu

AU - Cuc, Nguyen Thi

AU - Tai, Bui Huu

AU - Kiem, Phan Van

AU - Minh, Chau Van

AU - Kang, Ki Sung

AU - Kim, Seung Huyn

AU - Nhiem, Nguyen Xuan

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.99-2017.340 . Publisher Copyright: © 2020 Phytochemical Society of Europe

PY - 2020/6

Y1 - 2020/6

N2 - Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%).

AB - Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%).

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DO - 10.1016/j.phytol.2020.04.013

M3 - Article

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SN - 1874-3900

VL - 37

SP - 90

EP - 94

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity

Abstract

Bibliographical note

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