Prenatal prediction of neonatal death in single ventricle congenital heart disease

Seung Mi Lee, Jeong Eun Kwon, Sang Hoon Song, Gi Beom Kim, Jung Yeon Park, Byoung Jae Kim, Joon Ho Lee, Chan Wook Park, Joong Shin Park, Jong Kwan Jun

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: The objective of this study was to determine whether prenatal ultrasound findings and cord blood N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and cardiac troponin T (cTnT) can predict neonatal mortality in single ventricle congenital heart disease. Methods: The association between neonatal mortality and prenatal ultrasound findings/cord blood biomarkers was evaluated in neonates delivered with a diagnosis of single ventricle congenital heart disease. The presence of prenatal ultrasound findings suggesting systemic outflow obstruction (ascending aorta <2.5 percentile) or ventricular dysfunction (the presence of cardiomegaly or hydrops) was evaluated, and the total number of abnormal findings was converted to a numeric score called the 'single ventricle score'. In addition, NT pro-BNP and cTnT were measured in cord blood taken at the time of delivery. Results: A total of 48 cases of single ventricle congenital heart disease were included. The rate of neonatal mortality was 31% (15/48). The presence of either abnormal ultrasound findings(single ventricle score≥2) or elevated concentrations of NT pro-BNP or cTnT was associated with increased risk of neonatal death. Conclusion: The presence of either abnormal prenatal ultrasound findings or increased cord blood NT pro-BNP and cTnT concentrations was associated with the risk of neonatal death in single ventricle congenital heart disease.

Original languageEnglish
Pages (from-to)346-352
Number of pages7
JournalPrenatal Diagnosis
Volume36
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Genetics(clinical)

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