Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer

Jin Gu Lee, ByoungChul Cho, Mi Kyung Bae, Chang Young Lee, In Kyu Park, Dae Joon Kim, Songvogue Ahn, Kyung Young Chung

Research output: Contribution to journalArticle

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Abstract

Background: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. Methods: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. Results: Mean serum CRP level prior to surgery was 3.8 ± 4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r = 0.487, p < 0.001). Serum CRP levels were associated with sex (male vs. female, p = 0.003), smoking status (smoker vs. never smoker, p = 0.007), histology (squamous vs. non-squamous, p = 0.001), tumor size (size > 3 cm vs. size ≤ 3, p < 0.001), tumor necrosis (yes vs. no, p < 0.001), lymphovascular invasion (yes vs. no, p < 0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p = 0.013), but not with age (age > 64.5 vs. age ≤ 64.5, p = 0.508), atelectasis or obstructive pneumonia (yes vs. no, p = 0.119), location of tumor (peripheral vs. central, p = 0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p = 0.558). Multiple linear regression analysis indicated that pathologic tumor size (β = 0.583, p = 0.005) and lymphovascular invasion (β = 3.002, p = 0.009) were associated with preoperative serum CRP level. Conclusion: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalLung Cancer
Volume63
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Non-Small Cell Lung Carcinoma
C-Reactive Protein
Blood Proteins
Neoplasms
Linear Models
Regression Analysis
Pulmonary Atelectasis
Pneumonia
Analysis of Variance
Lymph Nodes
Lung

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Lee, Jin Gu ; Cho, ByoungChul ; Bae, Mi Kyung ; Lee, Chang Young ; Park, In Kyu ; Kim, Dae Joon ; Ahn, Songvogue ; Chung, Kyung Young. / Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer. In: Lung Cancer. 2009 ; Vol. 63, No. 1. pp. 106-110.
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title = "Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer",
abstract = "Background: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. Methods: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. Results: Mean serum CRP level prior to surgery was 3.8 ± 4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r = 0.487, p < 0.001). Serum CRP levels were associated with sex (male vs. female, p = 0.003), smoking status (smoker vs. never smoker, p = 0.007), histology (squamous vs. non-squamous, p = 0.001), tumor size (size > 3 cm vs. size ≤ 3, p < 0.001), tumor necrosis (yes vs. no, p < 0.001), lymphovascular invasion (yes vs. no, p < 0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p = 0.013), but not with age (age > 64.5 vs. age ≤ 64.5, p = 0.508), atelectasis or obstructive pneumonia (yes vs. no, p = 0.119), location of tumor (peripheral vs. central, p = 0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p = 0.558). Multiple linear regression analysis indicated that pathologic tumor size (β = 0.583, p = 0.005) and lymphovascular invasion (β = 3.002, p = 0.009) were associated with preoperative serum CRP level. Conclusion: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation.",
author = "Lee, {Jin Gu} and ByoungChul Cho and Bae, {Mi Kyung} and Lee, {Chang Young} and Park, {In Kyu} and Kim, {Dae Joon} and Songvogue Ahn and Chung, {Kyung Young}",
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Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer. / Lee, Jin Gu; Cho, ByoungChul; Bae, Mi Kyung; Lee, Chang Young; Park, In Kyu; Kim, Dae Joon; Ahn, Songvogue; Chung, Kyung Young.

In: Lung Cancer, Vol. 63, No. 1, 01.01.2009, p. 106-110.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer

AU - Lee, Jin Gu

AU - Cho, ByoungChul

AU - Bae, Mi Kyung

AU - Lee, Chang Young

AU - Park, In Kyu

AU - Kim, Dae Joon

AU - Ahn, Songvogue

AU - Chung, Kyung Young

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. Methods: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. Results: Mean serum CRP level prior to surgery was 3.8 ± 4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r = 0.487, p < 0.001). Serum CRP levels were associated with sex (male vs. female, p = 0.003), smoking status (smoker vs. never smoker, p = 0.007), histology (squamous vs. non-squamous, p = 0.001), tumor size (size > 3 cm vs. size ≤ 3, p < 0.001), tumor necrosis (yes vs. no, p < 0.001), lymphovascular invasion (yes vs. no, p < 0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p = 0.013), but not with age (age > 64.5 vs. age ≤ 64.5, p = 0.508), atelectasis or obstructive pneumonia (yes vs. no, p = 0.119), location of tumor (peripheral vs. central, p = 0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p = 0.558). Multiple linear regression analysis indicated that pathologic tumor size (β = 0.583, p = 0.005) and lymphovascular invasion (β = 3.002, p = 0.009) were associated with preoperative serum CRP level. Conclusion: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation.

AB - Background: This study focused on the association between preoperative serum C-reactive protein (CRP) levels and pathologic parameters in patients with resected non-small cell lung cancer (NSCLC). Our primary objective was to find pathologic factors that may explain poor prognosis in patients with preoperative serum CRP elevation. Methods: The records of 102 patients who had undergone pulmonary resection of NSCLC were reviewed. The association between preoperative serum CRP levels and variables that had p-values of less than 0.05 in t-test or one-way ANOVA was examined using multiple linear regression analysis. Results: Mean serum CRP level prior to surgery was 3.8 ± 4.9 (range, 0.1-19.8) mg/dL. The Pearson correlation coefficient indicated that serum CRP level and pathologic tumor diameter are positively correlated (r = 0.487, p < 0.001). Serum CRP levels were associated with sex (male vs. female, p = 0.003), smoking status (smoker vs. never smoker, p = 0.007), histology (squamous vs. non-squamous, p = 0.001), tumor size (size > 3 cm vs. size ≤ 3, p < 0.001), tumor necrosis (yes vs. no, p < 0.001), lymphovascular invasion (yes vs. no, p < 0.001), and pleural invasion (P0 vs. P1 vs. P2 vs. P3, p = 0.013), but not with age (age > 64.5 vs. age ≤ 64.5, p = 0.508), atelectasis or obstructive pneumonia (yes vs. no, p = 0.119), location of tumor (peripheral vs. central, p = 0.474), and lymph node involvement (N0 vs. N1 vs. N2 vs. N3, p = 0.558). Multiple linear regression analysis indicated that pathologic tumor size (β = 0.583, p = 0.005) and lymphovascular invasion (β = 3.002, p = 0.009) were associated with preoperative serum CRP level. Conclusion: Our results indicate that lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level, which may be considered a prognostic factor in patients with NSCLC. This additional information might serve as a basis to explain poor prognosis in patients with preoperative serum CRP elevation.

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