Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

B. W. Park, J. W. Oh, J. H. Kim, S. H. Park, K. S. Kim, J. H. Kim, K. S. Lee

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Background: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. Materials and methods: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. Results: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. Conclusion: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.

Original languageEnglish
Pages (from-to)675-681
Number of pages7
JournalAnnals of Oncology
Volume19
Issue number4
DOIs
Publication statusPublished - 2008 Apr

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes'. Together they form a unique fingerprint.

  • Cite this

    Park, B. W., Oh, J. W., Kim, J. H., Park, S. H., Kim, K. S., Kim, J. H., & Lee, K. S. (2008). Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes. Annals of Oncology, 19(4), 675-681. https://doi.org/10.1093/annonc/mdm538