Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

B. W. Park, J. W. Oh, J. H. Kim, S. H. Park, K. S. Kim, J. H. Kim, K. S. Lee

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. Materials and methods: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. Results: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. Conclusion: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.

Original languageEnglish
Pages (from-to)675-681
Number of pages7
JournalAnnals of Oncology
Volume19
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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Carcinoembryonic Antigen
Breast Neoplasms
Antigens
Serum
Neoplasms
Multivariate Analysis
Neoplasm Metastasis
Differentiation Antigens
Neoplasm Antigens
Tumor Biomarkers
Tumor Burden
Estrogen Receptors
Disease-Free Survival
Survival

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Park, B. W., Oh, J. W., Kim, J. H., Park, S. H., Kim, K. S., Kim, J. H., & Lee, K. S. (2008). Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes. Annals of Oncology, 19(4), 675-681. https://doi.org/10.1093/annonc/mdm538
Park, B. W. ; Oh, J. W. ; Kim, J. H. ; Park, S. H. ; Kim, K. S. ; Kim, J. H. ; Lee, K. S. / Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes. In: Annals of Oncology. 2008 ; Vol. 19, No. 4. pp. 675-681.
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abstract = "Background: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. Materials and methods: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. Results: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4{\%}) and 79 (10.7{\%}) patients, respectively. Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. Conclusion: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.",
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Park, BW, Oh, JW, Kim, JH, Park, SH, Kim, KS, Kim, JH & Lee, KS 2008, 'Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes', Annals of Oncology, vol. 19, no. 4, pp. 675-681. https://doi.org/10.1093/annonc/mdm538

Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes. / Park, B. W.; Oh, J. W.; Kim, J. H.; Park, S. H.; Kim, K. S.; Kim, J. H.; Lee, K. S.

In: Annals of Oncology, Vol. 19, No. 4, 01.04.2008, p. 675-681.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

AU - Park, B. W.

AU - Oh, J. W.

AU - Kim, J. H.

AU - Park, S. H.

AU - Kim, K. S.

AU - Kim, J. H.

AU - Lee, K. S.

PY - 2008/4/1

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N2 - Background: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. Materials and methods: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. Results: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. Conclusion: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.

AB - Background: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer. Materials and methods: A total of 740 patients with stages I-III breast cancer had preoperative CA 15-3 and CEA concentrations measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinicopathological parameters and patient outcomes. Results: Among 740 patients, elevated preoperative levels of CA 15-3 and CEA were identified in 92 (12.4%) and 79 (10.7%) patients, respectively. Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 and CEA levels were associated with poor disease-free survival (DFS, P = 0.0014, P = 0.0001, respectively) and overall survival (OS, P = 0.018, P = 0.015) even in stage-matched analysis. Patients with normal levels of both CA 15-3 and CEA showed better DFS and OS than those with elevated group. In multivariate analysis, age (<35 years), tumor size (>2 cm), node metastases, estrogen receptor expression, and elevated CA 15-3 and CEA preoperative values were independent prognostic factors for DFS. Conclusion: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.

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U2 - 10.1093/annonc/mdm538

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