Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: A Korean multi-center review

Changhee Yoo, Cheol Young Oh, Se Joong Kim, Sun Il Kim, Young Sig Kim, Jong Yeon Park, Do Hwan Seong, Yun Seob Song, Won Jae Yang, Hyunchul Chung, In Rae Cho, Sung Yong Cho, Sang Hyeon Cheon, Sungjoon Hong, Jin Seon Cho

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH). Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated. Results: IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685). Conclusions: IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalKorean Journal of Urology
Volume53
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Prostatic Hyperplasia
Prostate-Specific Antigen
Prostatic Neoplasms
Digital Rectal Examination
Transurethral Resection of Prostate
Area Under Curve
Prostate
Prostatectomy
ROC Curve
Ultrasonography
Body Mass Index
Multivariate Analysis
Biopsy
Therapeutics
Population

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Yoo, Changhee ; Oh, Cheol Young ; Kim, Se Joong ; Kim, Sun Il ; Kim, Young Sig ; Park, Jong Yeon ; Seong, Do Hwan ; Song, Yun Seob ; Yang, Won Jae ; Chung, Hyunchul ; Cho, In Rae ; Cho, Sung Yong ; Cheon, Sang Hyeon ; Hong, Sungjoon ; Cho, Jin Seon. / Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia : A Korean multi-center review. In: Korean Journal of Urology. 2012 ; Vol. 53, No. 6. pp. 391-395.
@article{5c89bdf33692443c8f0078f78e113278,
title = "Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: A Korean multi-center review",
abstract = "Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH). Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated. Results: IPca was diagnosed in 78 patients (4.8{\%}). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685). Conclusions: IPca was detected in 4.8{\%} of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.",
author = "Changhee Yoo and Oh, {Cheol Young} and Kim, {Se Joong} and Kim, {Sun Il} and Kim, {Young Sig} and Park, {Jong Yeon} and Seong, {Do Hwan} and Song, {Yun Seob} and Yang, {Won Jae} and Hyunchul Chung and Cho, {In Rae} and Cho, {Sung Yong} and Cheon, {Sang Hyeon} and Sungjoon Hong and Cho, {Jin Seon}",
year = "2012",
month = "6",
day = "1",
doi = "10.4111/kju.2012.53.6.391",
language = "English",
volume = "53",
pages = "391--395",
journal = "Korean Journal of Urology",
issn = "2005-6737",
publisher = "Korean Urological Association",
number = "6",

}

Yoo, C, Oh, CY, Kim, SJ, Kim, SI, Kim, YS, Park, JY, Seong, DH, Song, YS, Yang, WJ, Chung, H, Cho, IR, Cho, SY, Cheon, SH, Hong, S & Cho, JS 2012, 'Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: A Korean multi-center review', Korean Journal of Urology, vol. 53, no. 6, pp. 391-395. https://doi.org/10.4111/kju.2012.53.6.391

Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia : A Korean multi-center review. / Yoo, Changhee; Oh, Cheol Young; Kim, Se Joong; Kim, Sun Il; Kim, Young Sig; Park, Jong Yeon; Seong, Do Hwan; Song, Yun Seob; Yang, Won Jae; Chung, Hyunchul; Cho, In Rae; Cho, Sung Yong; Cheon, Sang Hyeon; Hong, Sungjoon; Cho, Jin Seon.

In: Korean Journal of Urology, Vol. 53, No. 6, 01.06.2012, p. 391-395.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia

T2 - A Korean multi-center review

AU - Yoo, Changhee

AU - Oh, Cheol Young

AU - Kim, Se Joong

AU - Kim, Sun Il

AU - Kim, Young Sig

AU - Park, Jong Yeon

AU - Seong, Do Hwan

AU - Song, Yun Seob

AU - Yang, Won Jae

AU - Chung, Hyunchul

AU - Cho, In Rae

AU - Cho, Sung Yong

AU - Cheon, Sang Hyeon

AU - Hong, Sungjoon

AU - Cho, Jin Seon

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH). Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated. Results: IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685). Conclusions: IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.

AB - Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH). Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated. Results: IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685). Conclusions: IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.

UR - http://www.scopus.com/inward/record.url?scp=84863844540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863844540&partnerID=8YFLogxK

U2 - 10.4111/kju.2012.53.6.391

DO - 10.4111/kju.2012.53.6.391

M3 - Article

C2 - 22741046

AN - SCOPUS:84863844540

VL - 53

SP - 391

EP - 395

JO - Korean Journal of Urology

JF - Korean Journal of Urology

SN - 2005-6737

IS - 6

ER -