Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: A Korean multi-center review

Changhee Yoo, Cheol Young Oh, Se Joong Kim, Sun Il Kim, Young Sig Kim, Jong Yeon Park, Do Hwan Seong, Yun Seob Song, Won Jae Yang, Hyun Chul Chung, In Rae Cho, Sung Yong Cho, Sang Hyeon Cheon, Sungjoon Hong, Jin Seon Cho

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Abstract

Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH). Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated. Results: IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685). Conclusions: IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalKorean Journal of Urology
Volume53
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

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All Science Journal Classification (ASJC) codes

  • Urology

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Yoo, C., Oh, C. Y., Kim, S. J., Kim, S. I., Kim, Y. S., Park, J. Y., Seong, D. H., Song, Y. S., Yang, W. J., Chung, H. C., Cho, I. R., Cho, S. Y., Cheon, S. H., Hong, S., & Cho, J. S. (2012). Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: A Korean multi-center review. Korean Journal of Urology, 53(6), 391-395. https://doi.org/10.4111/kju.2012.53.6.391