Preoperative levels of plasma micronutrients are related to endometrial cancer risk

Nan Hee Jeong, Eun Seop Song, Jong Min Lee, Kwang Beom Lee, Mi Kyung Kim, Young Mi Yun, Jae Kwan Lee, Sung Kyong Son, Jung Pil Lee, Jae-Hoon Kim, Soo Young Hur, Yong Il Kwon

Research output: Contribution to journalArticle

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Abstract

Objective. To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Seven tertiary medical institutes in Korea. Population. Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period.Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.Main outcome measures. Effect of micronutrients on endometrial cancer risk.Results. The mean concentration of plasma -carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and -tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of -carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma -carotene and lycopene had a 0.12-fold (95% confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95% CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), -tocopherol (p for trend=0.322), and -tocopherol (p for trend=0.087) showed no association with endometrial cancer risk.Conclusions. Plasma levels of -carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.

Original languageEnglish
Pages (from-to)434-439
Number of pages6
JournalActa obstetricia et gynecologica Scandinavica
Volume88
Issue number4
DOIs
Publication statusPublished - 2009 Jul 30

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Micronutrients
Endometrial Neoplasms
Tocopherols
Carotenoids
Lutein
Vitamin A
Confidence Intervals
Korea
Oral Contraceptives
Menopause
Parity
Alcohol Drinking
Case-Control Studies
Body Mass Index
Antioxidants
Logistic Models
Smoking
High Pressure Liquid Chromatography
Outcome Assessment (Health Care)
lycopene

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Jeong, N. H., Song, E. S., Lee, J. M., Lee, K. B., Kim, M. K., Yun, Y. M., ... Kwon, Y. I. (2009). Preoperative levels of plasma micronutrients are related to endometrial cancer risk. Acta obstetricia et gynecologica Scandinavica, 88(4), 434-439. https://doi.org/10.1080/00016340902767187
Jeong, Nan Hee ; Song, Eun Seop ; Lee, Jong Min ; Lee, Kwang Beom ; Kim, Mi Kyung ; Yun, Young Mi ; Lee, Jae Kwan ; Son, Sung Kyong ; Lee, Jung Pil ; Kim, Jae-Hoon ; Hur, Soo Young ; Kwon, Yong Il. / Preoperative levels of plasma micronutrients are related to endometrial cancer risk. In: Acta obstetricia et gynecologica Scandinavica. 2009 ; Vol. 88, No. 4. pp. 434-439.
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title = "Preoperative levels of plasma micronutrients are related to endometrial cancer risk",
abstract = "Objective. To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Seven tertiary medical institutes in Korea. Population. Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period.Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.Main outcome measures. Effect of micronutrients on endometrial cancer risk.Results. The mean concentration of plasma -carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and -tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of -carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma -carotene and lycopene had a 0.12-fold (95{\%} confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95{\%} CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), -tocopherol (p for trend=0.322), and -tocopherol (p for trend=0.087) showed no association with endometrial cancer risk.Conclusions. Plasma levels of -carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.",
author = "Jeong, {Nan Hee} and Song, {Eun Seop} and Lee, {Jong Min} and Lee, {Kwang Beom} and Kim, {Mi Kyung} and Yun, {Young Mi} and Lee, {Jae Kwan} and Son, {Sung Kyong} and Lee, {Jung Pil} and Jae-Hoon Kim and Hur, {Soo Young} and Kwon, {Yong Il}",
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Jeong, NH, Song, ES, Lee, JM, Lee, KB, Kim, MK, Yun, YM, Lee, JK, Son, SK, Lee, JP, Kim, J-H, Hur, SY & Kwon, YI 2009, 'Preoperative levels of plasma micronutrients are related to endometrial cancer risk', Acta obstetricia et gynecologica Scandinavica, vol. 88, no. 4, pp. 434-439. https://doi.org/10.1080/00016340902767187

Preoperative levels of plasma micronutrients are related to endometrial cancer risk. / Jeong, Nan Hee; Song, Eun Seop; Lee, Jong Min; Lee, Kwang Beom; Kim, Mi Kyung; Yun, Young Mi; Lee, Jae Kwan; Son, Sung Kyong; Lee, Jung Pil; Kim, Jae-Hoon; Hur, Soo Young; Kwon, Yong Il.

In: Acta obstetricia et gynecologica Scandinavica, Vol. 88, No. 4, 30.07.2009, p. 434-439.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preoperative levels of plasma micronutrients are related to endometrial cancer risk

AU - Jeong, Nan Hee

AU - Song, Eun Seop

AU - Lee, Jong Min

AU - Lee, Kwang Beom

AU - Kim, Mi Kyung

AU - Yun, Young Mi

AU - Lee, Jae Kwan

AU - Son, Sung Kyong

AU - Lee, Jung Pil

AU - Kim, Jae-Hoon

AU - Hur, Soo Young

AU - Kwon, Yong Il

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Objective. To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Seven tertiary medical institutes in Korea. Population. Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period.Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.Main outcome measures. Effect of micronutrients on endometrial cancer risk.Results. The mean concentration of plasma -carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and -tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of -carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma -carotene and lycopene had a 0.12-fold (95% confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95% CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), -tocopherol (p for trend=0.322), and -tocopherol (p for trend=0.087) showed no association with endometrial cancer risk.Conclusions. Plasma levels of -carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.

AB - Objective. To examine the relation between the plasma concentration of antioxidant micronutrients and endometrial cancer risk in Korean women. Design. Hospital-based case-control study. Setting. Seven tertiary medical institutes in Korea. Population. Incidence of 28 endometrial cancer cases were identified and 140 age-matched controls selected for the same period.Methods. Preoperative plasma concentrations of -carotene, lycopene, zeaxanthin plus lutein, retinol, -tocopherol, and -tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Conditional logistic regression was used to evaluate micronutrient effect after adjustment for body mass index (BMI), menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.Main outcome measures. Effect of micronutrients on endometrial cancer risk.Results. The mean concentration of plasma -carotene (p=0.001), lycopene (p=0.008), zeaxanthin plus lutein (p=0.031), retinol (p=0.048), and -tocopherol (p=0.046) were significantly lower in endometrial cancer patients than in controls. Plasma levels of -carotene (p for trend=0.0007) and lycopene (p for trend=0.007) were inversely associated with endometrial cancer risk across tertiles. Women in the highest tertile of plasma -carotene and lycopene had a 0.12-fold (95% confidence intervals (CIs) 0.03-0.48) and 0.15-fold (95% CIs 0.04-0.61) decreased risk of endometrial cancer compared to women in the lowest tertile, respectively. Other micronutrients such as zeaxanthin plus lutein (p for trend=0.142), retinol (p for trend=0.108), -tocopherol (p for trend=0.322), and -tocopherol (p for trend=0.087) showed no association with endometrial cancer risk.Conclusions. Plasma levels of -carotene and lycopene are inversely associated with the risk of endometrial cancer in Korean women.

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