Preoperative low serum bicarbonate levels predict acute kidney injury after cardiac surgery

Su Young Jung, Jung Tak Park, Young Eun Kwon, Hyung Woo Kim, Geun Woo Ryu, Sul A. Lee, Seohyun Park, Jong Hyun Jhee, Hyung Jung Oh, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang

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4 Citations (Scopus)

Abstract

Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. Although lower than normal serum bicarbonate levels are known to be associated with consecutive renal function deterioration in patients with chronic kidney injury, it is not well-known whether preoperative low serum bicarbonate levels are associated with the development of AKI in patients who undergo cardiac surgery. Therefore, the clinical implication of preoperative serum bicarbonate levels on AKI occurrence after cardiac surgery was investigated. Patients who underwent coronary artery bypass or valve surgery at Yonsei University Health System from January 2013 to December 2014 were enrolled. The patients were divided into 3 groups based on preoperative serum bicarbonate levels, which represented group 1 (below normal levels) <23 mEq/L; group 2 (normal levels) 23 to 24 mEq/L; and group 3 (elevated levels) >24 mEq/L. The primary outcome was the predicated incidence of AKI 48 hours after cardiac surgery. AKI was defined according to Acute Kidney Injury Network criteria. Among 875 patients, 228 (26.1%) developed AKI within 48 hours after cardiac surgery. The incidence of AKI was higher in group 1 (40.9%) than in group 2 (26.5%) and group 3 (19.5%) (P<0.001). In addition, the duration of postoperative stay in a hospital intensive care unit (ICU) was longer for AKI patients and for those in the low-preoperative-serum-bicarbonate-level groups. A multivariate logistic regression analysis showed that low preoperative serum bicarbonate levels were significantly associated with AKI even after adjustment for age, sex, hypertension, diabetes mellitus, operation type, preoperative hemoglobin, and estimated glomerular filtration rate. In conclusion, low serum bicarbonate levels were associated with higher incidence of AKI and prolonged ICU stay. Further studies are needed to clarify whether strict correction of bicarbonate levels close to normal limits may have a protective role in preventing further AKI development.

Original languageEnglish
Pages (from-to)e3216
JournalMedicine (United States)
Volume95
Issue number13
DOIs
Publication statusPublished - 2016 Jan 1

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Bicarbonates
Acute Kidney Injury
Thoracic Surgery
Serum
Intensive Care Units
Incidence
Kidney
Glomerular Filtration Rate
Coronary Artery Bypass
Diabetes Mellitus
Hemoglobins
Logistic Models
Regression Analysis
Hypertension

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jung, Su Young ; Park, Jung Tak ; Kwon, Young Eun ; Kim, Hyung Woo ; Ryu, Geun Woo ; Lee, Sul A. ; Park, Seohyun ; Jhee, Jong Hyun ; Oh, Hyung Jung ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Kang, Shin Wook. / Preoperative low serum bicarbonate levels predict acute kidney injury after cardiac surgery. In: Medicine (United States). 2016 ; Vol. 95, No. 13. pp. e3216.
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abstract = "Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. Although lower than normal serum bicarbonate levels are known to be associated with consecutive renal function deterioration in patients with chronic kidney injury, it is not well-known whether preoperative low serum bicarbonate levels are associated with the development of AKI in patients who undergo cardiac surgery. Therefore, the clinical implication of preoperative serum bicarbonate levels on AKI occurrence after cardiac surgery was investigated. Patients who underwent coronary artery bypass or valve surgery at Yonsei University Health System from January 2013 to December 2014 were enrolled. The patients were divided into 3 groups based on preoperative serum bicarbonate levels, which represented group 1 (below normal levels) <23 mEq/L; group 2 (normal levels) 23 to 24 mEq/L; and group 3 (elevated levels) >24 mEq/L. The primary outcome was the predicated incidence of AKI 48 hours after cardiac surgery. AKI was defined according to Acute Kidney Injury Network criteria. Among 875 patients, 228 (26.1{\%}) developed AKI within 48 hours after cardiac surgery. The incidence of AKI was higher in group 1 (40.9{\%}) than in group 2 (26.5{\%}) and group 3 (19.5{\%}) (P<0.001). In addition, the duration of postoperative stay in a hospital intensive care unit (ICU) was longer for AKI patients and for those in the low-preoperative-serum-bicarbonate-level groups. A multivariate logistic regression analysis showed that low preoperative serum bicarbonate levels were significantly associated with AKI even after adjustment for age, sex, hypertension, diabetes mellitus, operation type, preoperative hemoglobin, and estimated glomerular filtration rate. In conclusion, low serum bicarbonate levels were associated with higher incidence of AKI and prolonged ICU stay. Further studies are needed to clarify whether strict correction of bicarbonate levels close to normal limits may have a protective role in preventing further AKI development.",
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Preoperative low serum bicarbonate levels predict acute kidney injury after cardiac surgery. / Jung, Su Young; Park, Jung Tak; Kwon, Young Eun; Kim, Hyung Woo; Ryu, Geun Woo; Lee, Sul A.; Park, Seohyun; Jhee, Jong Hyun; Oh, Hyung Jung; Han, Seung Hyeok; Yoo, Tae Hyun; Kang, Shin Wook.

In: Medicine (United States), Vol. 95, No. 13, 01.01.2016, p. e3216.

Research output: Contribution to journalArticle

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AU - Jung, Su Young

AU - Park, Jung Tak

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