Preoperative nomograms for predicting extracapsular extension in korean men with localized prostate cancer

A multi-institutional clinicopathologic study

Jae Seung Chung, Han Yong Choi, Hae Ryoung Song, Seok Soo Byun, Seongil Seo, Cheryn Song, Jin Seon Cho, Sang Eun Lee, Hanjong Ahn, Eun Sik Lee, Won Jae Kim, Moon Kee Chung, Tae Young Jung, Ho Song Yu, Youngdeuk Choi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5%) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy.

Original languageEnglish
Pages (from-to)1443-1448
Number of pages6
JournalJournal of Korean medical science
Volume25
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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Nomograms
Prostatic Neoplasms
Prostatectomy
ROC Curve
Biopsy
Neoplasm Grading
Prostate-Specific Antigen
Logistic Models
Regression Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chung, Jae Seung ; Choi, Han Yong ; Song, Hae Ryoung ; Byun, Seok Soo ; Seo, Seongil ; Song, Cheryn ; Cho, Jin Seon ; Lee, Sang Eun ; Ahn, Hanjong ; Lee, Eun Sik ; Kim, Won Jae ; Chung, Moon Kee ; Jung, Tae Young ; Yu, Ho Song ; Choi, Youngdeuk. / Preoperative nomograms for predicting extracapsular extension in korean men with localized prostate cancer : A multi-institutional clinicopathologic study. In: Journal of Korean medical science. 2010 ; Vol. 25, No. 10. pp. 1443-1448.
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abstract = "We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5{\%}) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy.",
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Chung, JS, Choi, HY, Song, HR, Byun, SS, Seo, S, Song, C, Cho, JS, Lee, SE, Ahn, H, Lee, ES, Kim, WJ, Chung, MK, Jung, TY, Yu, HS & Choi, Y 2010, 'Preoperative nomograms for predicting extracapsular extension in korean men with localized prostate cancer: A multi-institutional clinicopathologic study', Journal of Korean medical science, vol. 25, no. 10, pp. 1443-1448. https://doi.org/10.3346/jkms.2010.25.10.1443

Preoperative nomograms for predicting extracapsular extension in korean men with localized prostate cancer : A multi-institutional clinicopathologic study. / Chung, Jae Seung; Choi, Han Yong; Song, Hae Ryoung; Byun, Seok Soo; Seo, Seongil; Song, Cheryn; Cho, Jin Seon; Lee, Sang Eun; Ahn, Hanjong; Lee, Eun Sik; Kim, Won Jae; Chung, Moon Kee; Jung, Tae Young; Yu, Ho Song; Choi, Youngdeuk.

In: Journal of Korean medical science, Vol. 25, No. 10, 01.10.2010, p. 1443-1448.

Research output: Contribution to journalArticle

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T1 - Preoperative nomograms for predicting extracapsular extension in korean men with localized prostate cancer

T2 - A multi-institutional clinicopathologic study

AU - Chung, Jae Seung

AU - Choi, Han Yong

AU - Song, Hae Ryoung

AU - Byun, Seok Soo

AU - Seo, Seongil

AU - Song, Cheryn

AU - Cho, Jin Seon

AU - Lee, Sang Eun

AU - Ahn, Hanjong

AU - Lee, Eun Sik

AU - Kim, Won Jae

AU - Chung, Moon Kee

AU - Jung, Tae Young

AU - Yu, Ho Song

AU - Choi, Youngdeuk

PY - 2010/10/1

Y1 - 2010/10/1

N2 - We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5%) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy.

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