Preparation and characterization of chitosan microparticles intended for controlled drug delivery

J. A. Ko, H. J. Park, Sung Joo Hwang, J. B. Park, J. S. Lee

Research output: Contribution to journalArticle

326 Citations (Scopus)

Abstract

Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 μm and encapsulation efficiencies of drug were more than 90%. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing MW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery system to control the release of drug.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume249
Issue number1-2
DOIs
Publication statusPublished - 2002 Dec 5

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Chitosan
Pharmaceutical Preparations
Felodipine
Molecular Weight
Drug and Narcotic Control
triphosphoric acid
Particle Size
Electron Scanning Microscopy

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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abstract = "Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 μm and encapsulation efficiencies of drug were more than 90{\%}. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing MW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery system to control the release of drug.",
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Preparation and characterization of chitosan microparticles intended for controlled drug delivery. / Ko, J. A.; Park, H. J.; Hwang, Sung Joo; Park, J. B.; Lee, J. S.

In: International Journal of Pharmaceutics, Vol. 249, No. 1-2, 05.12.2002, p. 165-174.

Research output: Contribution to journalArticle

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AU - Ko, J. A.

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