Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method

B. K. Kim, Sung Joo Hwang, J. B. Park, H. J. Park

Research output: Contribution to journalReview article

102 Citations (Scopus)

Abstract

Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4%. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.

Original languageEnglish
Pages (from-to)811-822
Number of pages12
JournalJournal of Microencapsulation
Volume19
Issue number6
DOIs
Publication statusPublished - 2002 Nov 1

Fingerprint

Drug Compounding
Emulsions
Microspheres
emulsions
Evaporation
drugs
evaporation
preparation
Pharmaceutical Preparations
hypertension
polymers
acrylates
profiles
Encapsulation
acetonitrile
copolymers
proportion
Polymers
electron microscopes
Felodipine

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4{\%}. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.",
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Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method. / Kim, B. K.; Hwang, Sung Joo; Park, J. B.; Park, H. J.

In: Journal of Microencapsulation, Vol. 19, No. 6, 01.11.2002, p. 811-822.

Research output: Contribution to journalReview article

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