Abstract
The aim of the present study was to investigate the effect of Soluplus® on the solubility of atorvastatin calcium and to develop a solid dispersion formulation that can improve the oral bioavailability of atorvastatin calcium. We demonstrated that Soluplus® increases the aqueous solubility of atorvastatin calcium. Several solid dispersion formulations of atorvastatin calcium with Soluplus ® were prepared at various drug: carrier ratios by spray drying. Physicochemical analysis demonstrated that atorvastatin calcium is amorphous in each solid dispersion, and the 2:8 drug: carrier ratio provided the highest degree of sustained atorvastatin supersaturation. Pharmacokinetic analysis in rats revealed that the 2:8 dispersion significantly improved the oral bioavailability of atorvastatin. This study demonstrates that spray-dried Soluplus ® solid dispersions can be an effective method for achieving higher atorvastatin plasma levels.
Original language | English |
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Pages (from-to) | 545-551 |
Number of pages | 7 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 62 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2014 Jun |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Drug Discovery