Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

Chong Kook Kim; Sang A. Ryuu; Kyung Mi Park; Soo Jeong Lim; Sung Joo Hwang

doi:10.1016/S0378-5173(96)04791-6

Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

Chong Kook Kim, Sang A. Ryuu, Kyung Mi Park, Soo Jeong Lim, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).

Original language	English
Pages (from-to)	131-134
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/S0378-5173(96)04791-6
Publication status	Published - 1997 Feb 14

Bibliographical note

Funding Information:
This work was partially supportedb y the re-searchg rantfrom Korea Sciencea nd Engineering Foundation( KOSEF 94-0403-18-3).

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1016/S0378-5173(96)04791-6

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title = "Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A",

abstract = "To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam{\textregistered}P-.0, GP-20), Poloxamer 123 (Pluronic{\textregistered}43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).",

author = "Kim, {Chong Kook} and Ryuu, {Sang A.} and Park, {Kyung Mi} and Lim, {Soo Jeong} and Hwang, {Sung Joo}",

note = "Funding Information: This work was partially supportedb y the re-searchg rantfrom Korea Sciencea nd Engineering Foundation( KOSEF 94-0403-18-3).",

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doi = "10.1016/S0378-5173(96)04791-6",

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T1 - Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

AU - Kim, Chong Kook

AU - Ryuu, Sang A.

AU - Park, Kyung Mi

AU - Lim, Soo Jeong

AU - Hwang, Sung Joo

N1 - Funding Information: This work was partially supportedb y the re-searchg rantfrom Korea Sciencea nd Engineering Foundation( KOSEF 94-0403-18-3).

PY - 1997/2/14

Y1 - 1997/2/14

N2 - To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).

AB - To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).

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Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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