Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

Chong Kook Kim, Sang A. Ryuu, Kyung Mi Park, Soo Jeong Lim, Sung Joo Hwang

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume147
Issue number1
DOIs
Publication statusPublished - 1997 Feb 14

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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