To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).
Bibliographical noteFunding Information:
This work was partially supportedb y the re-searchg rantfrom Korea Sciencea nd Engineering Foundation( KOSEF 94-0403-18-3).
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science