Preparation and physicochemical characterization of phase inverted water/oil microemulsion containing cyclosporin A

Chong Kook Kim, Sang A. Ryuu, Kyung Mi Park, Soo Jeong Lim, Sung Joo Hwang

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46 Citations (Scopus)

Abstract

To improve the solubility of cyclosporin A, microemulsion systems containing cyclosporin A. was developed. The system was optimized by evaluating the solubility of cyclosporin A and the phase-inversion efficiency after the preparation of microemulsions with varying compositions of ethyl oleate, cyclosporin A and surfactant-cosurfactant mixtures (Polypropyleneglycol-20 methyl glucose ether (Glucam®P-.0, GP-20), Poloxamer 123 (Pluronic®43, PL43)). Microemulsion systems in this study could markedly improve the solubility of cyclosporin A and the most stable and homogeneous system was obtained with microemulsion containing 15% (w/w) of cyclosporin A prepared with 60% (w/w) of surfactant-cosurfactant mixture (PLA3:GP-20 = 1:1).

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume147
Issue number1
DOIs
Publication statusPublished - 1997 Feb 14

Bibliographical note

Funding Information:
This work was partially supportedb y the re-searchg rantfrom Korea Sciencea nd Engineering Foundation( KOSEF 94-0403-18-3).

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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