Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors

Nobuhiro Nishiyama, Keiji Itaka, Naoki Kanayama, Shigeto Fukushima, Kanjiro Miyata, Woo Dong Jang, Ung Li Chung, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to conferencePaper

Abstract

Poly(ethylene glycol)-poly(2-[(2-aminoethyl)amino] ethyl aspartamide) (PEG-DET) is an efficient synthetic vector, which was found in our laboratory. In this study, the efficient transfection and low cytotoxicity of PEG-DET was clarified from the viewpoint of its chemical structure. Also, the biological significance of PEG-DET was demonstrated from the viewpoint of its transfection efficiency and cytotoxicity to various cell lines including primary culture cells.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

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Polyethylene glycols
Cytotoxicity
Cell culture
Cells

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Nishiyama, N., Itaka, K., Kanayama, N., Fukushima, S., Miyata, K., Jang, W. D., ... Kataoka, K. (2005). Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.
Nishiyama, Nobuhiro ; Itaka, Keiji ; Kanayama, Naoki ; Fukushima, Shigeto ; Miyata, Kanjiro ; Jang, Woo Dong ; Chung, Ung Li ; Yamasaki, Yuichi ; Kataoka, Kazunori. / Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.1 p.
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abstract = "Poly(ethylene glycol)-poly(2-[(2-aminoethyl)amino] ethyl aspartamide) (PEG-DET) is an efficient synthetic vector, which was found in our laboratory. In this study, the efficient transfection and low cytotoxicity of PEG-DET was clarified from the viewpoint of its chemical structure. Also, the biological significance of PEG-DET was demonstrated from the viewpoint of its transfection efficiency and cytotoxicity to various cell lines including primary culture cells.",
author = "Nobuhiro Nishiyama and Keiji Itaka and Naoki Kanayama and Shigeto Fukushima and Kanjiro Miyata and Jang, {Woo Dong} and Chung, {Ung Li} and Yuichi Yamasaki and Kazunori Kataoka",
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Nishiyama, N, Itaka, K, Kanayama, N, Fukushima, S, Miyata, K, Jang, WD, Chung, UL, Yamasaki, Y & Kataoka, K 2005, 'Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors', Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan, 05/5/25 - 05/5/27.

Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors. / Nishiyama, Nobuhiro; Itaka, Keiji; Kanayama, Naoki; Fukushima, Shigeto; Miyata, Kanjiro; Jang, Woo Dong; Chung, Ung Li; Yamasaki, Yuichi; Kataoka, Kazunori.

2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors

AU - Nishiyama, Nobuhiro

AU - Itaka, Keiji

AU - Kanayama, Naoki

AU - Fukushima, Shigeto

AU - Miyata, Kanjiro

AU - Jang, Woo Dong

AU - Chung, Ung Li

AU - Yamasaki, Yuichi

AU - Kataoka, Kazunori

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Poly(ethylene glycol)-poly(2-[(2-aminoethyl)amino] ethyl aspartamide) (PEG-DET) is an efficient synthetic vector, which was found in our laboratory. In this study, the efficient transfection and low cytotoxicity of PEG-DET was clarified from the viewpoint of its chemical structure. Also, the biological significance of PEG-DET was demonstrated from the viewpoint of its transfection efficiency and cytotoxicity to various cell lines including primary culture cells.

AB - Poly(ethylene glycol)-poly(2-[(2-aminoethyl)amino] ethyl aspartamide) (PEG-DET) is an efficient synthetic vector, which was found in our laboratory. In this study, the efficient transfection and low cytotoxicity of PEG-DET was clarified from the viewpoint of its chemical structure. Also, the biological significance of PEG-DET was demonstrated from the viewpoint of its transfection efficiency and cytotoxicity to various cell lines including primary culture cells.

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Nishiyama N, Itaka K, Kanayama N, Fukushima S, Miyata K, Jang WD et al. Preparation, characterization and biological significance of PEG-b-PET block catiomers as efficient synthetic vectors. 2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.