Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Hui Li, Chang Hee Lee, Injae Shin

Research output: Contribution to journalArticle

Abstract

To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H2O2-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.

Original languageEnglish
Pages (from-to)4628-4631
Number of pages4
JournalOrganic Letters
Volume21
Issue number12
DOIs
Publication statusPublished - 2019 Jun 21

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cancer
Cells
Infrared radiation
Imaging techniques
preparation
probes
Neoplasms
Cathepsin B
Octreotide
Dipeptides
cells
Fluorophores
selectivity
Ligands
interference
ligands
acids
Substrates
somatostatin receptor 2
benzeneboronic acid

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H2O2-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.",
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Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging. / Li, Hui; Lee, Chang Hee; Shin, Injae.

In: Organic Letters, Vol. 21, No. 12, 21.06.2019, p. 4628-4631.

Research output: Contribution to journalArticle

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