Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Hui Li; Chang Hee Lee; Injae Shin

doi:10.1021/acs.orglett.9b01530

Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Hui Li, Chang Hee Lee, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H₂O₂-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.

Original language	English
Pages (from-to)	4628-4631
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	12
DOIs	https://doi.org/10.1021/acs.orglett.9b01530
Publication status	Published - 2019 Jun 21

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acs.orglett.9b01530

Cite this

@article{c363b41027a94db29bb386f508ab6ac5,

title = "Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging",

abstract = "To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H2O2-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.",

author = "Hui Li and Lee, {Chang Hee} and Injae Shin",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = jun,

day = "21",

doi = "10.1021/acs.orglett.9b01530",

language = "English",

volume = "21",

pages = "4628--4631",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

AU - Li, Hui

AU - Lee, Chang Hee

AU - Shin, Injae

PY - 2019/6/21

Y1 - 2019/6/21

N2 - To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H2O2-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.

AB - To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H2O2-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.

UR - http://www.scopus.com/inward/record.url?scp=85067018279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067018279&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.9b01530

DO - 10.1021/acs.orglett.9b01530

M3 - Article

C2 - 31184188

AN - SCOPUS:85067018279

SN - 1523-7060

VL - 21

SP - 4628

EP - 4631

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this