Preparation of chitosan microspheres using membrane emulsification and its size modelling

S. B. Park, Y. J. Jeon, Seungjoo Haam, H. Y. Park, W. S. Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The chitosan microspheres were prepared by a membrane emulsification method with variations of the N 2 gas pressure and the chitosan concentration. The pressure of N 2 gas was varied within the range from 0.2 × 10 5 to 0.8 × 10 5 Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was varied between 0.5-2.0 wt% at 0.4 × 10 5 Pa of N 2 gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N 2 gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration.

Original languageEnglish
Pages (from-to)539-552
Number of pages14
JournalJournal of Microencapsulation
Volume21
Issue number5
DOIs
Publication statusPublished - 2004 Aug 1

Fingerprint

Emulsification
Chitosan
Microspheres
membranes
Membranes
Pressure
preparation
Gases
Surface Tension
gas pressure
Surface tension
interfacial tension
Emulsions
emulsions
gases

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

Park, S. B. ; Jeon, Y. J. ; Haam, Seungjoo ; Park, H. Y. ; Kim, W. S. / Preparation of chitosan microspheres using membrane emulsification and its size modelling. In: Journal of Microencapsulation. 2004 ; Vol. 21, No. 5. pp. 539-552.
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Preparation of chitosan microspheres using membrane emulsification and its size modelling. / Park, S. B.; Jeon, Y. J.; Haam, Seungjoo; Park, H. Y.; Kim, W. S.

In: Journal of Microencapsulation, Vol. 21, No. 5, 01.08.2004, p. 539-552.

Research output: Contribution to journalArticle

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