Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Aastha Kukreja, Byunghoon Kang, Hyun Ouk Kim, Eunji Jang, Hye Young Son, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.

Original languageEnglish
Pages (from-to)56-65
Number of pages10
JournalJournal of Industrial and Engineering Chemistry
Volume48
DOIs
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (2012050077 and 2015M3A9D7029834). This research was supported by the Development of Platform Technology for Innovative Medical Measurements Program from Korea research Institute of Standards and Science (KRISS-2016-16011064).

Publisher Copyright:
© 2016 The Korean Society of Industrial and Engineering Chemistry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

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