Micelles are widely used in drug delivery owing to their attractive properties such as controllable drug release rates and the ability to target certain locations by conjugating with specific molecules. However, with the current state of understanding, only the core–shell and corona sites of micelles can be utilized. To form a micelle, each block copolymer was dissolved in DMF and then dropped into a polar solvent. Polymer micelles were formed through the agglomeration of the hydrophobic part that constituted a non-polar core and a hydrophilic corona. In this study, poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP) and poly(styrene)-block-poly(acrylic acid) (PS-b-PAA) formed micelles with a PS core in water. The hydrophobic PS domains were insoluble in the aqueous phase, which led to aggregation. Furthermore, from the pH-sensitive characteristic of weak polyelectrolyte, the changing of pH condition has an affected to the degree of ionization. Due to their characteristics, we prepared micelles from block copolymers at various pH values to increase the functionality of the micelles.
|Number of pages||6|
|Journal||Colloids and Surfaces A: Physicochemical and Engineering Aspects|
|Publication status||Published - 2018 Jan 20|
Bibliographical noteFunding Information:
This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIT [ 2016M3A9C6917405 ]. Additionally, this research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic of Korea ( HI14C-3266 , HI15C-1653 ). Also this research is supported by " The Project of Conversion by the Past R&D Results " through the Ministry of Trade, Industry and Energy (MOTIE) and the Korea Institute for Advancement of Technology (KIAT) ( N0002496 , 2017).
© 2017 Elsevier B.V.
All Science Journal Classification (ASJC) codes
- Surfaces and Interfaces
- Physical and Theoretical Chemistry
- Colloid and Surface Chemistry