Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method

Hye Young Kwon, Jun Young Lee, Sung Wook Choi, Yangsoo Jang, Jung Hyun Kim

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Nano-sized poly (D,L lactide-co-glycolide) (PLGA) particles, widely used as a biodegradable polymeric carrier, containing estrogen were prepared employing emulsification-diffusion method. Estrogen was chosen as a model drug. The preparation method consists of emulsifying a solution of polymer and drug in the aqueous phase containing stabilizer, previously saturated, followed by adding excess water. Influence of process variables on the mean particle size of nanoparticles has been studied. It was clarified that the type and concentrations of stabilizer, homogenizer speed, polymer concentration determined the size of PLGA nanoparticles. Especially when didodecyl dimethyl ammonium bromide (DMAB) was used as a stabilizer, estrogen containing nanoparticles of smaller than 100 nm was obtained.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume182
Issue number1-3
DOIs
Publication statusPublished - 2001 Jun 30

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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