Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

J. Yang, S. B. Park, Ho Geun Yoon, Y. M. Huh, S. Haam

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume324
Issue number2
DOIs
Publication statusPublished - 2006 Nov 6

Fingerprint

Magnetite Nanoparticles
Drug Carriers
Nanoparticles
Ferrosoferric Oxide
Surface Properties
Fourier Transform Infrared Spectroscopy
Magnetic Fields
Emulsions
Electrons
polycaprolactone
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{f39ba909a9904077be9b31823da85d35,
title = "Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier",
abstract = "Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.",
author = "J. Yang and Park, {S. B.} and Yoon, {Ho Geun} and Huh, {Y. M.} and S. Haam",
year = "2006",
month = "11",
day = "6",
doi = "10.1016/j.ijpharm.2006.06.029",
language = "English",
volume = "324",
pages = "185--190",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier. / Yang, J.; Park, S. B.; Yoon, Ho Geun; Huh, Y. M.; Haam, S.

In: International Journal of Pharmaceutics, Vol. 324, No. 2, 06.11.2006, p. 185-190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier

AU - Yang, J.

AU - Park, S. B.

AU - Yoon, Ho Geun

AU - Huh, Y. M.

AU - Haam, S.

PY - 2006/11/6

Y1 - 2006/11/6

N2 - Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

AB - Magnetic poly ε-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method. The influence of some preparative variables on the size and surface property was investigated. Nanoparticles were smooth, well individualized and homogeneous in size. The presence of magnetite and its superparamagnetic characteristic were confirmed by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR) and vibrating sample magnetometer (VSM), respectively. The anti-cancer drug was encapsulated in the magnetic nanoparticle during preparation. A typical release behavior was observed for 30 days. In vitro experiment of magnetic susceptibility under external magnetic field demonstrated that the magnetic PCL nanoparticles have sufficient magnetic susceptibility for a potential magnetic drug carrier for targeted delivery.

UR - http://www.scopus.com/inward/record.url?scp=33749517310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749517310&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2006.06.029

DO - 10.1016/j.ijpharm.2006.06.029

M3 - Article

C2 - 16872766

AN - SCOPUS:33749517310

VL - 324

SP - 185

EP - 190

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -