Abstract
Aim: To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides. Materials and methods: Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed. Results: Necrosis and moderate nuclear size variation were common features of PCNSL and GM. PCNSL characteristically showed apoptosis, lack of a fibrillary background, monotonous nuclei, scant cytoplasm, lack of microvascular proliferation, and presence of perivascular cuffing. Multivariate analysis revealed that presence of apoptosis was the most powerful predictive parameter for the diagnosis of PCNSL. Conclusion: The presence of apoptosis was effective for the intraoperative diagnosis of PCNSL compared to GM.
| Original language | English |
|---|---|
| Pages (from-to) | 105-111 |
| Number of pages | 7 |
| Journal | Clinical Neuropathology |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 May 1 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Neurology
- Clinical Neurology
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Presence of apoptosis distinguishes primary central nervous system lymphoma from glioblastoma during intraoperative consultation. / Cha, Yoon Jin; Choi, Junjeong; Kim, SeHoon.
In: Clinical Neuropathology, Vol. 37, No. 3, 01.05.2018, p. 105-111.Research output: Contribution to journal › Article
TY - JOUR
T1 - Presence of apoptosis distinguishes primary central nervous system lymphoma from glioblastoma during intraoperative consultation
AU - Cha, Yoon Jin
AU - Choi, Junjeong
AU - Kim, SeHoon
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Aim: To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides. Materials and methods: Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed. Results: Necrosis and moderate nuclear size variation were common features of PCNSL and GM. PCNSL characteristically showed apoptosis, lack of a fibrillary background, monotonous nuclei, scant cytoplasm, lack of microvascular proliferation, and presence of perivascular cuffing. Multivariate analysis revealed that presence of apoptosis was the most powerful predictive parameter for the diagnosis of PCNSL. Conclusion: The presence of apoptosis was effective for the intraoperative diagnosis of PCNSL compared to GM.
AB - Aim: To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides. Materials and methods: Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed. Results: Necrosis and moderate nuclear size variation were common features of PCNSL and GM. PCNSL characteristically showed apoptosis, lack of a fibrillary background, monotonous nuclei, scant cytoplasm, lack of microvascular proliferation, and presence of perivascular cuffing. Multivariate analysis revealed that presence of apoptosis was the most powerful predictive parameter for the diagnosis of PCNSL. Conclusion: The presence of apoptosis was effective for the intraoperative diagnosis of PCNSL compared to GM.
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U2 - 10.5414/NP301075
DO - 10.5414/NP301075
M3 - Article
VL - 37
SP - 105
EP - 111
JO - Clinical Neuropathology
JF - Clinical Neuropathology
SN - 0722-5091
IS - 3
ER -