Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation

Myoung Soo Kim, Hae Jin Kim, Soon Il Kim, Hyung Joon Ahn, Man Ki Ju, Hyun Jung Kim, Kyung Ock Jeon, Yu Seun Kim

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18 Citations (Scopus)

Abstract

BACKGROUND. Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum. METHODS. Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free). RESULTS. The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5±11.4 months of follow-up (P=0.5901). High sCD30 (≥115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9% vs. 22.4%, P=0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3% vs. 7.7%, P=0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P<0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx. CONCLUSION. PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.

Original languageEnglish
Pages (from-to)1602-1605
Number of pages4
JournalTransplantation
Volume82
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1

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Living Donors
Graft Rejection
Kidney Transplantation
Creatinine
Serum
Graft Survival
Incidence
Kidney
Immunosuppression
Hepatitis
Survival Rate
Biomarkers
Body Weight
Regression Analysis
Tissue Donors
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Kim, Myoung Soo ; Kim, Hae Jin ; Kim, Soon Il ; Ahn, Hyung Joon ; Ju, Man Ki ; Kim, Hyun Jung ; Jeon, Kyung Ock ; Kim, Yu Seun. / Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation. In: Transplantation. 2006 ; Vol. 82, No. 12. pp. 1602-1605.
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title = "Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation",
abstract = "BACKGROUND. Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum. METHODS. Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free). RESULTS. The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5±11.4 months of follow-up (P=0.5901). High sCD30 (≥115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9{\%} vs. 22.4{\%}, P=0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3{\%} vs. 7.7{\%}, P=0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P<0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx. CONCLUSION. PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.",
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Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation. / Kim, Myoung Soo; Kim, Hae Jin; Kim, Soon Il; Ahn, Hyung Joon; Ju, Man Ki; Kim, Hyun Jung; Jeon, Kyung Ock; Kim, Yu Seun.

In: Transplantation, Vol. 82, No. 12, 01.12.2006, p. 1602-1605.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation

AU - Kim, Myoung Soo

AU - Kim, Hae Jin

AU - Kim, Soon Il

AU - Ahn, Hyung Joon

AU - Ju, Man Ki

AU - Kim, Hyun Jung

AU - Jeon, Kyung Ock

AU - Kim, Yu Seun

PY - 2006/12/1

Y1 - 2006/12/1

N2 - BACKGROUND. Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum. METHODS. Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free). RESULTS. The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5±11.4 months of follow-up (P=0.5901). High sCD30 (≥115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9% vs. 22.4%, P=0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3% vs. 7.7%, P=0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P<0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx. CONCLUSION. PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.

AB - BACKGROUND. Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum. METHODS. Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free). RESULTS. The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5±11.4 months of follow-up (P=0.5901). High sCD30 (≥115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9% vs. 22.4%, P=0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3% vs. 7.7%, P=0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P<0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx. CONCLUSION. PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.

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