Pretreatment inflammatory markers predicting treatment outcomes in colorectal cancer

Sanghyun An, Hongjin Shim, Kwangmin Kim, Bora Kim, Hui Jae Bang, Hyejin Do, Hyang Rae Lee, Youngwan Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We aimed to review whether pretreatment inflammatory markers reflect the short- and long-term outcomes of patients with colon cancer, rectal cancer, colon and rectal cancers, and metastatic colorectal cancer (CRC). We found that pretreatment complete blood count and blood chemistry tests reflect short-term and long-term oncological outcomes in patients with CRC. Specifically, in patients with colon cancer, hypoalbuminemia was associated with worse postoperative morbidity, mortality, and inferior survival. In patients with rectal cancer, elevated neutrophil-lymphocyte ratio (NLR) and thrombocytosis were associated with postoperative complications, poor overall survival (OS), and disease-free survival (DFS). A high C-reactive protein/albumin ratio (CAR) was associated with poor OS and DFS. In patients with metastatic CRC, increased NLR and platelet-lymphocyte ratio (PLR) were associated with poor OS, DFS, and progression-free survival (PFS). In addition, high CAR and a low albumin/globulin ratio on blood chemistry tests were associated with poor OS and PFS. Although universal cut-off values were not available, various types of pretreatment laboratory markers could be utilized as adjuncts to predict prognosis in patients with CRC.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalAnnals of Coloproctology
Issue number2
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF 2017R1D1A3-B03032301).

Publisher Copyright:
© 2022 The Korean Society of Coloproctology.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology


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