Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix

Y. T. Kim, B. S. Yoon, J. W. Kim, S. H. Kim, J. Y. Kwon, J. H. Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Objectives: To investigate whether pretreatment levels of serum squamous cell carcinoma antigen (SCCA) and urine polyamines can predict lymph node metastases in patients with early stage cervical carcinoma. Methods: Pretreatment measurement of serum SCCA and urine polyamine levels was carried out for 419 women. Of those women, 104 with stage IB and IIA cancer received radical surgery and had tumor size reassessed postoperatively. Results: The women had increased levels of serum SCCA (> 2.0 ng/mL) and elevated urine polyamines (> 45 μmol/g of creatinine) with advanced cancer stage (P < 0.01). The median SCCA level was significantly higher in women with metastatic disease than that in those without lymph node involvement (3.9 vs. 1.1; P < 0.01). Women with nodal involvement also had significantly higher median levels of urine polyamines than those without nodal disease. Conclusions: Pretreatment measurement of SCCA and urine polyamine levels may help in predicting lymph node metastases in women with early stage cervical carcinoma.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume91
Issue number1
DOIs
Publication statusPublished - 2005 Oct

Bibliographical note

Funding Information:
This study was supported by Brain Korea 21 Project for Medical Science, Yonsei University.

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix'. Together they form a unique fingerprint.

Cite this