Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix

YoungTae Kim, B. S. Yoon, J. W. Kim, S. H. Kim, J. Y. Kwon, Jae-Hoon Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: To investigate whether pretreatment levels of serum squamous cell carcinoma antigen (SCCA) and urine polyamines can predict lymph node metastases in patients with early stage cervical carcinoma. Methods: Pretreatment measurement of serum SCCA and urine polyamine levels was carried out for 419 women. Of those women, 104 with stage IB and IIA cancer received radical surgery and had tumor size reassessed postoperatively. Results: The women had increased levels of serum SCCA (> 2.0 ng/mL) and elevated urine polyamines (> 45 μmol/g of creatinine) with advanced cancer stage (P < 0.01). The median SCCA level was significantly higher in women with metastatic disease than that in those without lymph node involvement (3.9 vs. 1.1; P < 0.01). Women with nodal involvement also had significantly higher median levels of urine polyamines than those without nodal disease. Conclusions: Pretreatment measurement of SCCA and urine polyamine levels may help in predicting lymph node metastases in women with early stage cervical carcinoma.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume91
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Polyamines
Cervix Uteri
Squamous Cell Carcinoma
Urine
Serum
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Neoplasms
squamous cell carcinoma-related antigen
Creatinine

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

@article{d06b420f3830416e951486ffc06a1f1d,
title = "Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix",
abstract = "Objectives: To investigate whether pretreatment levels of serum squamous cell carcinoma antigen (SCCA) and urine polyamines can predict lymph node metastases in patients with early stage cervical carcinoma. Methods: Pretreatment measurement of serum SCCA and urine polyamine levels was carried out for 419 women. Of those women, 104 with stage IB and IIA cancer received radical surgery and had tumor size reassessed postoperatively. Results: The women had increased levels of serum SCCA (> 2.0 ng/mL) and elevated urine polyamines (> 45 μmol/g of creatinine) with advanced cancer stage (P < 0.01). The median SCCA level was significantly higher in women with metastatic disease than that in those without lymph node involvement (3.9 vs. 1.1; P < 0.01). Women with nodal involvement also had significantly higher median levels of urine polyamines than those without nodal disease. Conclusions: Pretreatment measurement of SCCA and urine polyamine levels may help in predicting lymph node metastases in women with early stage cervical carcinoma.",
author = "YoungTae Kim and Yoon, {B. S.} and Kim, {J. W.} and Kim, {S. H.} and Kwon, {J. Y.} and Jae-Hoon Kim",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/j.ijgo.2005.06.010",
language = "English",
volume = "91",
pages = "47--52",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix. / Kim, YoungTae; Yoon, B. S.; Kim, J. W.; Kim, S. H.; Kwon, J. Y.; Kim, Jae-Hoon.

In: International Journal of Gynecology and Obstetrics, Vol. 91, No. 1, 01.01.2005, p. 47-52.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pretreatment levels of serum squamous cell carcinoma antigen and urine polyamines in women with squamous cell carcinoma of the cervix

AU - Kim, YoungTae

AU - Yoon, B. S.

AU - Kim, J. W.

AU - Kim, S. H.

AU - Kwon, J. Y.

AU - Kim, Jae-Hoon

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Objectives: To investigate whether pretreatment levels of serum squamous cell carcinoma antigen (SCCA) and urine polyamines can predict lymph node metastases in patients with early stage cervical carcinoma. Methods: Pretreatment measurement of serum SCCA and urine polyamine levels was carried out for 419 women. Of those women, 104 with stage IB and IIA cancer received radical surgery and had tumor size reassessed postoperatively. Results: The women had increased levels of serum SCCA (> 2.0 ng/mL) and elevated urine polyamines (> 45 μmol/g of creatinine) with advanced cancer stage (P < 0.01). The median SCCA level was significantly higher in women with metastatic disease than that in those without lymph node involvement (3.9 vs. 1.1; P < 0.01). Women with nodal involvement also had significantly higher median levels of urine polyamines than those without nodal disease. Conclusions: Pretreatment measurement of SCCA and urine polyamine levels may help in predicting lymph node metastases in women with early stage cervical carcinoma.

AB - Objectives: To investigate whether pretreatment levels of serum squamous cell carcinoma antigen (SCCA) and urine polyamines can predict lymph node metastases in patients with early stage cervical carcinoma. Methods: Pretreatment measurement of serum SCCA and urine polyamine levels was carried out for 419 women. Of those women, 104 with stage IB and IIA cancer received radical surgery and had tumor size reassessed postoperatively. Results: The women had increased levels of serum SCCA (> 2.0 ng/mL) and elevated urine polyamines (> 45 μmol/g of creatinine) with advanced cancer stage (P < 0.01). The median SCCA level was significantly higher in women with metastatic disease than that in those without lymph node involvement (3.9 vs. 1.1; P < 0.01). Women with nodal involvement also had significantly higher median levels of urine polyamines than those without nodal disease. Conclusions: Pretreatment measurement of SCCA and urine polyamine levels may help in predicting lymph node metastases in women with early stage cervical carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=24644455172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644455172&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2005.06.010

DO - 10.1016/j.ijgo.2005.06.010

M3 - Article

C2 - 16048726

AN - SCOPUS:24644455172

VL - 91

SP - 47

EP - 52

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 1

ER -