Abstract
Phenolic glycolipid I (PGL-I) is a Mycobacterium leprae-specific antigen and the antibodies to the antigen may suggest an M leprae infection. To compare the M. leprae transmission among the populations, we compared the prevalence of anti-PGL-I IgM antibodies among household contacts and controls between Korea and the Philippines. In Korea (prevalence of leprosy- 0.04:1000), the prevalence of anti-PGL-I antibodies were 4.8% among controls and 8.0% among contacts, respectively. On the other hand, the seroprevalence rate was 10.8% among controls and 13.4% among contacts in the Philippines (prevalence of leprosy-0.70:1000). Interestingly, a marked difference was noted in the prevalance of anti-PGL-I antibodies among children between the countries; 10-14% among children under 10 years old and 15-18% among those aged between 10 and 19 in the Philippines compared to 0% and 2.9-6.4% in Korea, respectively. This study, therefore suggests that a high prevalance of anti-PGL-I IgM antibodies among children may indicate an active transmission of M. leprae, resulting in a higher incidence of leprosy in the population.
| Original language | English |
|---|---|
| Pages (from-to) | 12-20 |
| Number of pages | 9 |
| Journal | Leprosy Review |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1992 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Prevalance of IgM antibodies to phenolic glycolipid I among household contacts and controls in Korea and the Philippines. / Cho, Sangnae; Kim, S. H.; Cellona, R. V.; Chan, G. P.; Fajardo, T. T.; Walsh, G. P.; Kim, J. D.
In: Leprosy Review, Vol. 63, No. 1, 01.01.1992, p. 12-20.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prevalance of IgM antibodies to phenolic glycolipid I among household contacts and controls in Korea and the Philippines
AU - Cho, Sangnae
AU - Kim, S. H.
AU - Cellona, R. V.
AU - Chan, G. P.
AU - Fajardo, T. T.
AU - Walsh, G. P.
AU - Kim, J. D.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Phenolic glycolipid I (PGL-I) is a Mycobacterium leprae-specific antigen and the antibodies to the antigen may suggest an M leprae infection. To compare the M. leprae transmission among the populations, we compared the prevalence of anti-PGL-I IgM antibodies among household contacts and controls between Korea and the Philippines. In Korea (prevalence of leprosy- 0.04:1000), the prevalence of anti-PGL-I antibodies were 4.8% among controls and 8.0% among contacts, respectively. On the other hand, the seroprevalence rate was 10.8% among controls and 13.4% among contacts in the Philippines (prevalence of leprosy-0.70:1000). Interestingly, a marked difference was noted in the prevalance of anti-PGL-I antibodies among children between the countries; 10-14% among children under 10 years old and 15-18% among those aged between 10 and 19 in the Philippines compared to 0% and 2.9-6.4% in Korea, respectively. This study, therefore suggests that a high prevalance of anti-PGL-I IgM antibodies among children may indicate an active transmission of M. leprae, resulting in a higher incidence of leprosy in the population.
AB - Phenolic glycolipid I (PGL-I) is a Mycobacterium leprae-specific antigen and the antibodies to the antigen may suggest an M leprae infection. To compare the M. leprae transmission among the populations, we compared the prevalence of anti-PGL-I IgM antibodies among household contacts and controls between Korea and the Philippines. In Korea (prevalence of leprosy- 0.04:1000), the prevalence of anti-PGL-I antibodies were 4.8% among controls and 8.0% among contacts, respectively. On the other hand, the seroprevalence rate was 10.8% among controls and 13.4% among contacts in the Philippines (prevalence of leprosy-0.70:1000). Interestingly, a marked difference was noted in the prevalance of anti-PGL-I antibodies among children between the countries; 10-14% among children under 10 years old and 15-18% among those aged between 10 and 19 in the Philippines compared to 0% and 2.9-6.4% in Korea, respectively. This study, therefore suggests that a high prevalance of anti-PGL-I IgM antibodies among children may indicate an active transmission of M. leprae, resulting in a higher incidence of leprosy in the population.
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U2 - 10.5935/0305-7518.19920003
DO - 10.5935/0305-7518.19920003
M3 - Article
VL - 63
SP - 12
EP - 20
JO - Leprosy Review
JF - Leprosy Review
SN - 0305-7518
IS - 1
ER -