Prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli

Yeon Joon Park, Jin Kyung Yu, Kang Gyun Park, Yong Gyu Park, Seongok Lee, Soo Young Kim, Seok Hoon Jeong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla CTX-M-14 and loss of OmpK36 were associated with higher carbapenem MICs.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume71
Issue number1
DOIs
Publication statusPublished - 2011 Sep

Bibliographical note

Funding Information:
We wish to thank all the contributing laboratories that provided isolates for this study. This work was supported by a research grant from the Korea Center for Disease Control (2009-E00520-00).

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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