Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Min Kyung Kang, Hyuk Jae Chang, Young Jin Kim, Ae Ran Park, Sungha Park, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalCoronary artery disease
Volume23
Issue number3
DOIs
Publication statusPublished - 2012 May 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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