Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Min Kyung Kang, Hyuk Jae Chang, Young Jin Kim, Ae Ran Park, Sungha Park, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalCoronary artery disease
Volume23
Issue number3
DOIs
Publication statusPublished - 2012 May 1

Fingerprint

Coronary Artery Disease
Albumins
Creatinine
Odds Ratio
Control Groups
Multidetector Computed Tomography
Regression Analysis
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{2e558e278744494a9ead111c2a399053,
title = "Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease",
abstract = "BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14{\%}, P<0.001) and at least 50{\%} subclinical CAD (16 vs. 2.5{\%}, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95{\%} confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.",
author = "Kang, {Min Kyung} and Chang, {Hyuk Jae} and Kim, {Young Jin} and Park, {Ae Ran} and Sungha Park and Yangsoo Jang and Namsik Chung",
year = "2012",
month = "5",
day = "1",
doi = "10.1097/MCA.0b013e3283515538",
language = "English",
volume = "23",
pages = "167--173",
journal = "Coronary Artery Disease",
issn = "0954-6928",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease. / Kang, Min Kyung; Chang, Hyuk Jae; Kim, Young Jin; Park, Ae Ran; Park, Sungha; Jang, Yangsoo; Chung, Namsik.

In: Coronary artery disease, Vol. 23, No. 3, 01.05.2012, p. 167-173.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

AU - Kang, Min Kyung

AU - Chang, Hyuk Jae

AU - Kim, Young Jin

AU - Park, Ae Ran

AU - Park, Sungha

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2012/5/1

Y1 - 2012/5/1

N2 - BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.

AB - BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.

UR - http://www.scopus.com/inward/record.url?scp=84862804554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862804554&partnerID=8YFLogxK

U2 - 10.1097/MCA.0b013e3283515538

DO - 10.1097/MCA.0b013e3283515538

M3 - Article

C2 - 22421547

AN - SCOPUS:84862804554

VL - 23

SP - 167

EP - 173

JO - Coronary Artery Disease

JF - Coronary Artery Disease

SN - 0954-6928

IS - 3

ER -