Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis

Donghee Han, Bríain ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Su Yeon Choi, Eun Ju Chun, Jidong Sung, Hae Won Han, Sung Hak Park, Tracy Callister, Fay Y. Lin, James K. Min, Hyuk-Jae Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The incidence of coronary artery disease (CAD) varies depending on ethnicity, but the precise differences remain to be firmly established. This study therefore evaluated the disparity in coronary artery calcification (CAC), as a marker of CAD, in asymptomatic US and Korean adults. Methods and Results: CAC score was compared between asymptomatic Korean (n=15,128) and US (n=7,533) adults. Propensity score matching was performed according to age, gender, hypertension, diabetes, dyslipidemia, and current smoking, which generated 2 cohorts of 5,427 matched pairs. Both cohorts were categorized according to age group: 45–54, 55–64, and 65–74 years. Overall, the prevalence of CAC score >0, >100, and >400 in Korean adults was lower than in US adults (P<0.001, all). According to increasing age groups, the likelihood of CAC was most often lower in Korean adults, especially in Korean women. The odds of having CAC >400 in Korean adults aged 65–74 years was 0.66 (95% CI: 0.48–0.91) overall, 0.78 (95% CI: 0.52–1.19) in men, and 0.50 (95% CI: 0.29–0.86) in women, compared with US counterparts. Conclusions: Korean adults have a lower prevalence and severity of atherosclerotic burden as assessed on CAC, compared with US adults, but the disparity in CAC according to ethnicity may decline with older age.

Original languageEnglish
Pages (from-to)2349-2355
Number of pages7
JournalCirculation Journal
Volume80
Issue number11
DOIs
Publication statusPublished - 2016 Jan 1

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Asymptomatic Diseases
Coronary Vessels
Coronary Artery Disease
Propensity Score
Dyslipidemias
Age Groups
Smoking
Hypertension
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Han, Donghee ; ó Hartaigh, Bríain ; Gransar, Heidi ; Lee, Ji Hyun ; Choi, Su Yeon ; Chun, Eun Ju ; Sung, Jidong ; Han, Hae Won ; Park, Sung Hak ; Callister, Tracy ; Lin, Fay Y. ; Min, James K. ; Chang, Hyuk-Jae. / Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis. In: Circulation Journal. 2016 ; Vol. 80, No. 11. pp. 2349-2355.
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title = "Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis",
abstract = "Background: The incidence of coronary artery disease (CAD) varies depending on ethnicity, but the precise differences remain to be firmly established. This study therefore evaluated the disparity in coronary artery calcification (CAC), as a marker of CAD, in asymptomatic US and Korean adults. Methods and Results: CAC score was compared between asymptomatic Korean (n=15,128) and US (n=7,533) adults. Propensity score matching was performed according to age, gender, hypertension, diabetes, dyslipidemia, and current smoking, which generated 2 cohorts of 5,427 matched pairs. Both cohorts were categorized according to age group: 45–54, 55–64, and 65–74 years. Overall, the prevalence of CAC score >0, >100, and >400 in Korean adults was lower than in US adults (P<0.001, all). According to increasing age groups, the likelihood of CAC was most often lower in Korean adults, especially in Korean women. The odds of having CAC >400 in Korean adults aged 65–74 years was 0.66 (95{\%} CI: 0.48–0.91) overall, 0.78 (95{\%} CI: 0.52–1.19) in men, and 0.50 (95{\%} CI: 0.29–0.86) in women, compared with US counterparts. Conclusions: Korean adults have a lower prevalence and severity of atherosclerotic burden as assessed on CAC, compared with US adults, but the disparity in CAC according to ethnicity may decline with older age.",
author = "Donghee Han and {{\'o} Hartaigh}, Br{\'i}ain and Heidi Gransar and Lee, {Ji Hyun} and Choi, {Su Yeon} and Chun, {Eun Ju} and Jidong Sung and Han, {Hae Won} and Park, {Sung Hak} and Tracy Callister and Lin, {Fay Y.} and Min, {James K.} and Hyuk-Jae Chang",
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Han, D, ó Hartaigh, B, Gransar, H, Lee, JH, Choi, SY, Chun, EJ, Sung, J, Han, HW, Park, SH, Callister, T, Lin, FY, Min, JK & Chang, H-J 2016, 'Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis', Circulation Journal, vol. 80, no. 11, pp. 2349-2355. https://doi.org/10.1253/circj.CJ-16-0762

Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis. / Han, Donghee; ó Hartaigh, Bríain; Gransar, Heidi; Lee, Ji Hyun; Choi, Su Yeon; Chun, Eun Ju; Sung, Jidong; Han, Hae Won; Park, Sung Hak; Callister, Tracy; Lin, Fay Y.; Min, James K.; Chang, Hyuk-Jae.

In: Circulation Journal, Vol. 80, No. 11, 01.01.2016, p. 2349-2355.

Research output: Contribution to journalArticle

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T1 - Prevalence and distribution of coronary artery calcification in asymptomatic United States and Korean adults – Cross-sectional propensity-matched analysis

AU - Han, Donghee

AU - ó Hartaigh, Bríain

AU - Gransar, Heidi

AU - Lee, Ji Hyun

AU - Choi, Su Yeon

AU - Chun, Eun Ju

AU - Sung, Jidong

AU - Han, Hae Won

AU - Park, Sung Hak

AU - Callister, Tracy

AU - Lin, Fay Y.

AU - Min, James K.

AU - Chang, Hyuk-Jae

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: The incidence of coronary artery disease (CAD) varies depending on ethnicity, but the precise differences remain to be firmly established. This study therefore evaluated the disparity in coronary artery calcification (CAC), as a marker of CAD, in asymptomatic US and Korean adults. Methods and Results: CAC score was compared between asymptomatic Korean (n=15,128) and US (n=7,533) adults. Propensity score matching was performed according to age, gender, hypertension, diabetes, dyslipidemia, and current smoking, which generated 2 cohorts of 5,427 matched pairs. Both cohorts were categorized according to age group: 45–54, 55–64, and 65–74 years. Overall, the prevalence of CAC score >0, >100, and >400 in Korean adults was lower than in US adults (P<0.001, all). According to increasing age groups, the likelihood of CAC was most often lower in Korean adults, especially in Korean women. The odds of having CAC >400 in Korean adults aged 65–74 years was 0.66 (95% CI: 0.48–0.91) overall, 0.78 (95% CI: 0.52–1.19) in men, and 0.50 (95% CI: 0.29–0.86) in women, compared with US counterparts. Conclusions: Korean adults have a lower prevalence and severity of atherosclerotic burden as assessed on CAC, compared with US adults, but the disparity in CAC according to ethnicity may decline with older age.

AB - Background: The incidence of coronary artery disease (CAD) varies depending on ethnicity, but the precise differences remain to be firmly established. This study therefore evaluated the disparity in coronary artery calcification (CAC), as a marker of CAD, in asymptomatic US and Korean adults. Methods and Results: CAC score was compared between asymptomatic Korean (n=15,128) and US (n=7,533) adults. Propensity score matching was performed according to age, gender, hypertension, diabetes, dyslipidemia, and current smoking, which generated 2 cohorts of 5,427 matched pairs. Both cohorts were categorized according to age group: 45–54, 55–64, and 65–74 years. Overall, the prevalence of CAC score >0, >100, and >400 in Korean adults was lower than in US adults (P<0.001, all). According to increasing age groups, the likelihood of CAC was most often lower in Korean adults, especially in Korean women. The odds of having CAC >400 in Korean adults aged 65–74 years was 0.66 (95% CI: 0.48–0.91) overall, 0.78 (95% CI: 0.52–1.19) in men, and 0.50 (95% CI: 0.29–0.86) in women, compared with US counterparts. Conclusions: Korean adults have a lower prevalence and severity of atherosclerotic burden as assessed on CAC, compared with US adults, but the disparity in CAC according to ethnicity may decline with older age.

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