Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea

Eun Hye Lee, Jung Mo Lee, youngae kang, Ah Young Leem, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Song Yee Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Abstract: Objective: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. Abstract: Setting and Design: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V. Abstract: Results: Diabetes prevalence was 24.2% (252/1044) among patients with PTB and 11.6% (1700/14,655) among controls. Diabetes [odds ratios (OR) 2.56, 95% confidence interval (CI) 1.56–4.21, P < 0.001], male sex (OR 1.93, 95% CI 1.08–3.44, P = 0.027), and cavitary disease (OR 2.08, 95% CI 1.29–3.35, P = 0.003) were significant risk factors for 2-month culture positivity. Diabetes was the only factor associated with unsuccessful treatment outcomes (OR 1.67, 95% CI 1.03–2.70, P = 0.039). Abstract: Conclusion: The prevalence of diabetes was markedly higher in patients with PTB than in a sample of the general South Korean population. Diabetes may delay sputum conversion and adversely affect treatment outcomes; detection and management of diabetes in patients with PTB is crucial.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalLung
DOIs
Publication statusPublished - 2017 Apr 1

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Republic of Korea
Pulmonary Tuberculosis
Diabetes Mellitus
Odds Ratio
Confidence Intervals
Tuberculosis
Sex Ratio
Sputum
Tertiary Care Centers
Population

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Lee, Eun Hye ; Lee, Jung Mo ; kang, youngae ; Leem, Ah Young ; Kim, Eun Young ; Jung, Ji Ye ; Park, Moo Suk ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Kim, Song Yee. / Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea. In: Lung. 2017 ; pp. 1-7.
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title = "Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea",
abstract = "Abstract: Objective: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. Abstract: Setting and Design: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V. Abstract: Results: Diabetes prevalence was 24.2{\%} (252/1044) among patients with PTB and 11.6{\%} (1700/14,655) among controls. Diabetes [odds ratios (OR) 2.56, 95{\%} confidence interval (CI) 1.56–4.21, P < 0.001], male sex (OR 1.93, 95{\%} CI 1.08–3.44, P = 0.027), and cavitary disease (OR 2.08, 95{\%} CI 1.29–3.35, P = 0.003) were significant risk factors for 2-month culture positivity. Diabetes was the only factor associated with unsuccessful treatment outcomes (OR 1.67, 95{\%} CI 1.03–2.70, P = 0.039). Abstract: Conclusion: The prevalence of diabetes was markedly higher in patients with PTB than in a sample of the general South Korean population. Diabetes may delay sputum conversion and adversely affect treatment outcomes; detection and management of diabetes in patients with PTB is crucial.",
author = "Lee, {Eun Hye} and Lee, {Jung Mo} and youngae kang and Leem, {Ah Young} and Kim, {Eun Young} and Jung, {Ji Ye} and Park, {Moo Suk} and Kim, {Young Sam} and Kim, {Se Kyu} and Joon Chang and Kim, {Song Yee}",
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Lee, EH, Lee, JM, kang, Y, Leem, AY, Kim, EY, Jung, JY, Park, MS, Kim, YS, Kim, SK, Chang, J & Kim, SY 2017, 'Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea', Lung, pp. 1-7. https://doi.org/10.1007/s00408-017-9978-4

Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea. / Lee, Eun Hye; Lee, Jung Mo; kang, youngae; Leem, Ah Young; Kim, Eun Young; Jung, Ji Ye; Park, Moo Suk; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Kim, Song Yee.

In: Lung, 01.04.2017, p. 1-7.

Research output: Contribution to journalArticle

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T1 - Prevalence and Impact of Diabetes Mellitus Among Patients with Active Pulmonary Tuberculosis in South Korea

AU - Lee, Eun Hye

AU - Lee, Jung Mo

AU - kang, youngae

AU - Leem, Ah Young

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - Park, Moo Suk

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Kim, Song Yee

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Y1 - 2017/4/1

N2 - Abstract: Objective: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. Abstract: Setting and Design: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V. Abstract: Results: Diabetes prevalence was 24.2% (252/1044) among patients with PTB and 11.6% (1700/14,655) among controls. Diabetes [odds ratios (OR) 2.56, 95% confidence interval (CI) 1.56–4.21, P < 0.001], male sex (OR 1.93, 95% CI 1.08–3.44, P = 0.027), and cavitary disease (OR 2.08, 95% CI 1.29–3.35, P = 0.003) were significant risk factors for 2-month culture positivity. Diabetes was the only factor associated with unsuccessful treatment outcomes (OR 1.67, 95% CI 1.03–2.70, P = 0.039). Abstract: Conclusion: The prevalence of diabetes was markedly higher in patients with PTB than in a sample of the general South Korean population. Diabetes may delay sputum conversion and adversely affect treatment outcomes; detection and management of diabetes in patients with PTB is crucial.

AB - Abstract: Objective: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. Abstract: Setting and Design: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V. Abstract: Results: Diabetes prevalence was 24.2% (252/1044) among patients with PTB and 11.6% (1700/14,655) among controls. Diabetes [odds ratios (OR) 2.56, 95% confidence interval (CI) 1.56–4.21, P < 0.001], male sex (OR 1.93, 95% CI 1.08–3.44, P = 0.027), and cavitary disease (OR 2.08, 95% CI 1.29–3.35, P = 0.003) were significant risk factors for 2-month culture positivity. Diabetes was the only factor associated with unsuccessful treatment outcomes (OR 1.67, 95% CI 1.03–2.70, P = 0.039). Abstract: Conclusion: The prevalence of diabetes was markedly higher in patients with PTB than in a sample of the general South Korean population. Diabetes may delay sputum conversion and adversely affect treatment outcomes; detection and management of diabetes in patients with PTB is crucial.

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