Prevalence and relationship of olfactory dysfunction and tinnitus among middle-and old-aged population in Korea

Do Yang Park, Hyun Jun Kim, Chang Hoon Kim, Jae Yong Lee, Kyungdo Han, Ji Ho Choi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Olfactory dysfunction and tinnitus are age-related otorhinolaryngological disorders with a high prevalence in the elderly population and share several common clinical features. However, there is no study investigating the relationship between these two diseases. We studied the prevalence of olfactory dysfunction and tinnitus among Koreans and studied the relationship between these two diseases based on the Korean National Health and Nutrition Examination Survey. The subjects of this study were enrolled from the Fifth Korean National Health and Nutrition Examination Survey (2010-2012, n = 25,534). Data of subjects aged 40 years and older who underwent physical examination and completed a self-reported questionnaire and other anthropometric variables were statistically analyzed. Odds ratios were calculated to identify the relationship between olfactory dysfunction and tinnitus, using multiple logistic regression models. Older males, non-smokers, non/lower alcohol drinker groups exhibited the relationship between olfactory dysfunction and tinnitus. Metabolic syndrome and mental health problems were associated with both olfactory dysfunction and tinnitus. After adjusting for confounding factors, olfactory dysfunction was significantly associated with tinnitus (OR 1.318). There was a dose-response relationship between tinnitus severity and the odds of olfactory dysfunction (ORs for mild, moderate and severe tinnitus were, respectively, 1.134, 1.569 and 2.044). Additional molecular genetics and animal studies are needed to determine the shared pathophysiology of the two diseases.

Original languageEnglish
Article numbere0206328
JournalPloS one
Volume13
Issue number10
DOIs
Publication statusPublished - 2018 Oct

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National Health and Nutrition Examination Survey
Tinnitus
Korea
Korean Peninsula
Nutrition
mental health
metabolic syndrome
pathophysiology
Health
molecular genetics
clinical examination
odds ratio
Population
dose response
questionnaires
alcohols
Medical problems
Logistics
Nutrition Surveys
Animals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Park, Do Yang ; Kim, Hyun Jun ; Kim, Chang Hoon ; Lee, Jae Yong ; Han, Kyungdo ; Choi, Ji Ho. / Prevalence and relationship of olfactory dysfunction and tinnitus among middle-and old-aged population in Korea. In: PloS one. 2018 ; Vol. 13, No. 10.
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Prevalence and relationship of olfactory dysfunction and tinnitus among middle-and old-aged population in Korea. / Park, Do Yang; Kim, Hyun Jun; Kim, Chang Hoon; Lee, Jae Yong; Han, Kyungdo; Choi, Ji Ho.

In: PloS one, Vol. 13, No. 10, e0206328, 10.2018.

Research output: Contribution to journalArticle

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