Prevalence and serogroup changes of Neisseria meningitidis in South Korea

Hyukmin Lee, Younghee Seo, Kyung Hyo Kim, Kyungwon Lee, Kang Won Choe

Research output: Contribution to journalArticle

Abstract

Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat. The most common serogroup was serogroup B (overall, 36%, n = 9/25; IMD, 37%, n = 7/19), which was isolated in every year of the research period except for 2011. There were five serogroup W isolates recovered from patients in military service. W was no longer isolated after initiation of a vaccine programme for military trainees, but serogroup B caused meningitis in an army recruit training centre in 2015. In MLST analysis, 14 sequence types were found, and all isolates belonging to W showed the same molecular epidemiologic characteristics (W:P1.5-1, 2-2:F3-9:ST-8912). All isolates showed susceptibility to ceftriaxone, meropenem, ciprofloxacin, minocycline, and rifampin; however, the susceptibility rates to penicillin and ampicillin for isolates with W and C capsules were 22% and 30%, respectively.

Original languageEnglish
Article number5292
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Republic of Korea
Neisseria meningitidis
meropenem
Vaccines
Minocycline
Ceftriaxone
Ampicillin
Rifampin
Ciprofloxacin
Pharynx
Microbiology
Sputum
Meningitis
Penicillins
Capsules
Cerebrospinal Fluid
Serogroup
Research

All Science Journal Classification (ASJC) codes

  • General

Cite this

Lee, Hyukmin ; Seo, Younghee ; Kim, Kyung Hyo ; Lee, Kyungwon ; Choe, Kang Won. / Prevalence and serogroup changes of Neisseria meningitidis in South Korea. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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Prevalence and serogroup changes of Neisseria meningitidis in South Korea. / Lee, Hyukmin; Seo, Younghee; Kim, Kyung Hyo; Lee, Kyungwon; Choe, Kang Won.

In: Scientific reports, Vol. 8, No. 1, 5292, 01.12.2018.

Research output: Contribution to journalArticle

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