Prevalence and seroprevalence of high-risk human papillomavirus infection

Min A. Kim, Jin Kyoung Oh, Doo Byung Chay, Dong Choon Park, Seok Mo Kim, Eun Suk Kang, Jae-Hoon Kim, Chi Heum Cho, Hai Rim Shin, Kyung Seo

Research output: Contribution to journalArticle

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Abstract

Objective: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. Methods: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. Results: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. Conclusion: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.

Original languageEnglish
Pages (from-to)932-940
Number of pages9
JournalObstetrics and Gynecology
Volume116
Issue number4
DOIs
Publication statusPublished - 2010 Jan 1

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Papillomavirus Infections
Seroepidemiologic Studies
Human papillomavirus 18
Human papillomavirus 16
Vaccines
Sexual Partners
Polymerase Chain Reaction
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Kim, M. A., Oh, J. K., Chay, D. B., Park, D. C., Kim, S. M., Kang, E. S., ... Seo, K. (2010). Prevalence and seroprevalence of high-risk human papillomavirus infection. Obstetrics and Gynecology, 116(4), 932-940. https://doi.org/10.1097/AOG.0b013e3181edbeba
Kim, Min A. ; Oh, Jin Kyoung ; Chay, Doo Byung ; Park, Dong Choon ; Kim, Seok Mo ; Kang, Eun Suk ; Kim, Jae-Hoon ; Cho, Chi Heum ; Shin, Hai Rim ; Seo, Kyung. / Prevalence and seroprevalence of high-risk human papillomavirus infection. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 4. pp. 932-940.
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abstract = "Objective: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. Methods: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. Results: The prevalence of genital high-risk HPV was 12.6{\%} among Korean women aged 20-59 years. It reached a peak of 23.2{\%} at 20-29 years of age, decreasing thereafter but increasing again to 12.4{\%} at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7{\%} among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4{\%} at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9{\%} at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4{\%} and 2.7{\%}, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. Conclusion: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.",
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Kim, MA, Oh, JK, Chay, DB, Park, DC, Kim, SM, Kang, ES, Kim, J-H, Cho, CH, Shin, HR & Seo, K 2010, 'Prevalence and seroprevalence of high-risk human papillomavirus infection', Obstetrics and Gynecology, vol. 116, no. 4, pp. 932-940. https://doi.org/10.1097/AOG.0b013e3181edbeba

Prevalence and seroprevalence of high-risk human papillomavirus infection. / Kim, Min A.; Oh, Jin Kyoung; Chay, Doo Byung; Park, Dong Choon; Kim, Seok Mo; Kang, Eun Suk; Kim, Jae-Hoon; Cho, Chi Heum; Shin, Hai Rim; Seo, Kyung.

In: Obstetrics and Gynecology, Vol. 116, No. 4, 01.01.2010, p. 932-940.

Research output: Contribution to journalArticle

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T1 - Prevalence and seroprevalence of high-risk human papillomavirus infection

AU - Kim, Min A.

AU - Oh, Jin Kyoung

AU - Chay, Doo Byung

AU - Park, Dong Choon

AU - Kim, Seok Mo

AU - Kang, Eun Suk

AU - Kim, Jae-Hoon

AU - Cho, Chi Heum

AU - Shin, Hai Rim

AU - Seo, Kyung

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objective: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. Methods: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. Results: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. Conclusion: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.

AB - Objective: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. Methods: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. Results: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. Conclusion: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.

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