Prevalence and seroprevalence of high-risk human papillomavirus infection

Min A. Kim, Jin Kyoung Oh, Doo Byung Chay, Dong Choon Park, Seok Mo Kim, Eun Suk Kang, Jae Hoon Kim, Chi Heum Cho, Hai Rim Shin, Kyung Seo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. Methods: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. Results: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. Conclusion: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy.

Original languageEnglish
Pages (from-to)932-940
Number of pages9
JournalObstetrics and Gynecology
Volume116
Issue number4
DOIs
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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