Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults

Donghee Han, Yang Gao, Bríain ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Asim Rizvi, Su Yeon Choi, Eun Ju Chun, Jidong Sung, Hae Won Han, Sung Hak Park, James K. Min, Bin Lu, Hyuk Jae Chang

Research output: Contribution to journalArticle

Abstract

Background Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations. Methods We generated 3 matched groups (n = 702) using a propensity scoring approach derived from a Korean (N = 48,901) and Chinese cohort (N = 927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012–2014; and (3) a past Korean group who underwent CACS scanning 8–10 years before the index group (2002–2006). We used logistic regression to generate odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: > 0 (any), > 100 (moderate), and > 400 (severe). Results The prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95% CI: 1.49–6.71, P-value < 0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95% CI: 1.17–2.15, P-value < 0.001) were significantly higher than in the past Korean group. Conclusions In this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalInternational Journal of Cardiology
Volume230
DOIs
Publication statusPublished - 2017 Mar 1

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Coronary Vessels
Calcium
Odds Ratio
Confidence Intervals
Cardiovascular Diseases
Population
Life Style
Research Design
Logistic Models

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Han, Donghee ; Gao, Yang ; ó Hartaigh, Bríain ; Gransar, Heidi ; Lee, Ji Hyun ; Rizvi, Asim ; Choi, Su Yeon ; Chun, Eun Ju ; Sung, Jidong ; Han, Hae Won ; Park, Sung Hak ; Min, James K. ; Lu, Bin ; Chang, Hyuk Jae. / Prevalence and severity of coronary artery calcification based on the epidemiologic pattern : A propensity matched comparison of asymptomatic Korean and Chinese adults. In: International Journal of Cardiology. 2017 ; Vol. 230. pp. 353-358.
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title = "Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults",
abstract = "Background Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations. Methods We generated 3 matched groups (n = 702) using a propensity scoring approach derived from a Korean (N = 48,901) and Chinese cohort (N = 927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012–2014; and (3) a past Korean group who underwent CACS scanning 8–10 years before the index group (2002–2006). We used logistic regression to generate odds ratios (OR) with 95{\%} confidence intervals (95{\%} CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: > 0 (any), > 100 (moderate), and > 400 (severe). Results The prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95{\%} CI: 1.49–6.71, P-value < 0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95{\%} CI: 1.17–2.15, P-value < 0.001) were significantly higher than in the past Korean group. Conclusions In this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.",
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Prevalence and severity of coronary artery calcification based on the epidemiologic pattern : A propensity matched comparison of asymptomatic Korean and Chinese adults. / Han, Donghee; Gao, Yang; ó Hartaigh, Bríain; Gransar, Heidi; Lee, Ji Hyun; Rizvi, Asim; Choi, Su Yeon; Chun, Eun Ju; Sung, Jidong; Han, Hae Won; Park, Sung Hak; Min, James K.; Lu, Bin; Chang, Hyuk Jae.

In: International Journal of Cardiology, Vol. 230, 01.03.2017, p. 353-358.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence and severity of coronary artery calcification based on the epidemiologic pattern

T2 - A propensity matched comparison of asymptomatic Korean and Chinese adults

AU - Han, Donghee

AU - Gao, Yang

AU - ó Hartaigh, Bríain

AU - Gransar, Heidi

AU - Lee, Ji Hyun

AU - Rizvi, Asim

AU - Choi, Su Yeon

AU - Chun, Eun Ju

AU - Sung, Jidong

AU - Han, Hae Won

AU - Park, Sung Hak

AU - Min, James K.

AU - Lu, Bin

AU - Chang, Hyuk Jae

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations. Methods We generated 3 matched groups (n = 702) using a propensity scoring approach derived from a Korean (N = 48,901) and Chinese cohort (N = 927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012–2014; and (3) a past Korean group who underwent CACS scanning 8–10 years before the index group (2002–2006). We used logistic regression to generate odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: > 0 (any), > 100 (moderate), and > 400 (severe). Results The prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95% CI: 1.49–6.71, P-value < 0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95% CI: 1.17–2.15, P-value < 0.001) were significantly higher than in the past Korean group. Conclusions In this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.

AB - Background Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations. Methods We generated 3 matched groups (n = 702) using a propensity scoring approach derived from a Korean (N = 48,901) and Chinese cohort (N = 927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012–2014; and (3) a past Korean group who underwent CACS scanning 8–10 years before the index group (2002–2006). We used logistic regression to generate odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: > 0 (any), > 100 (moderate), and > 400 (severe). Results The prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95% CI: 1.49–6.71, P-value < 0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95% CI: 1.17–2.15, P-value < 0.001) were significantly higher than in the past Korean group. Conclusions In this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.

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U2 - 10.1016/j.ijcard.2016.12.106

DO - 10.1016/j.ijcard.2016.12.106

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