Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease

Yong Soo Baek, Tae Hoon Kim, Jae Sun Uhm, Jong Yun Kim, huinam pak, Moon Hyoung Lee, Boyoung Joung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). Methods: In 20,772 consecutive ARD patients (mean age 42 ± 17 years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. Results: AF was observed in 235 (1.1%) patients. The mean duration to AF diagnoses was 5.9 ± 2.4 years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1 ± 0.7 vs. 2.7 ± 0.2 mg/L, p = 0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5%) and systemic sclerosis (2.3%) than that in other ARDs (all p < 0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95% CI: 1.04-1.06, p = 0.01), hypertension (HR 2.28, 95% CI: 1.70-3.06, p < 0.001), high CRP levels (HR 1.75, 95% CI: 1.07-2.86, p = 0.04), and heart failure (HR 11.96, 95% CI: 8.13-17.60, p = 0.03). During a mean follow-up period of 6.8 ± 4.5 years, ARD patients with AF had a higher all cause death (16.5% vs. 2.1%, p < 0.001) and incidence of strokes (1.9% vs. 0.4%, p = 0.001) than non-AF patients. Conclusions The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalInternational Journal of Cardiology
Volume214
DOIs
Publication statusPublished - 2016 Jul 1

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Rheumatic Diseases
Atrial Fibrillation
Autoimmune Diseases
Incidence
Heart Failure
Stroke
Hypertension
Myositis
Systemic Scleroderma
Tertiary Care Centers
Comorbidity
Coronary Artery Disease
Cause of Death
Multivariate Analysis
Inflammation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Baek, Yong Soo ; Kim, Tae Hoon ; Uhm, Jae Sun ; Kim, Jong Yun ; pak, huinam ; Lee, Moon Hyoung ; Joung, Boyoung. / Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease. In: International Journal of Cardiology. 2016 ; Vol. 214. pp. 4-9.
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title = "Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease",
abstract = "Background: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). Methods: In 20,772 consecutive ARD patients (mean age 42 ± 17 years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. Results: AF was observed in 235 (1.1{\%}) patients. The mean duration to AF diagnoses was 5.9 ± 2.4 years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1 ± 0.7 vs. 2.7 ± 0.2 mg/L, p = 0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5{\%}) and systemic sclerosis (2.3{\%}) than that in other ARDs (all p < 0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95{\%} CI: 1.04-1.06, p = 0.01), hypertension (HR 2.28, 95{\%} CI: 1.70-3.06, p < 0.001), high CRP levels (HR 1.75, 95{\%} CI: 1.07-2.86, p = 0.04), and heart failure (HR 11.96, 95{\%} CI: 8.13-17.60, p = 0.03). During a mean follow-up period of 6.8 ± 4.5 years, ARD patients with AF had a higher all cause death (16.5{\%} vs. 2.1{\%}, p < 0.001) and incidence of strokes (1.9{\%} vs. 0.4{\%}, p = 0.001) than non-AF patients. Conclusions The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up.",
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Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease. / Baek, Yong Soo; Kim, Tae Hoon; Uhm, Jae Sun; Kim, Jong Yun; pak, huinam; Lee, Moon Hyoung; Joung, Boyoung.

In: International Journal of Cardiology, Vol. 214, 01.07.2016, p. 4-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence and the clinical outcome of atrial fibrillation in patients with Autoimmune Rheumatic Disease

AU - Baek, Yong Soo

AU - Kim, Tae Hoon

AU - Uhm, Jae Sun

AU - Kim, Jong Yun

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AU - Lee, Moon Hyoung

AU - Joung, Boyoung

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N2 - Background: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). Methods: In 20,772 consecutive ARD patients (mean age 42 ± 17 years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. Results: AF was observed in 235 (1.1%) patients. The mean duration to AF diagnoses was 5.9 ± 2.4 years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1 ± 0.7 vs. 2.7 ± 0.2 mg/L, p = 0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5%) and systemic sclerosis (2.3%) than that in other ARDs (all p < 0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95% CI: 1.04-1.06, p = 0.01), hypertension (HR 2.28, 95% CI: 1.70-3.06, p < 0.001), high CRP levels (HR 1.75, 95% CI: 1.07-2.86, p = 0.04), and heart failure (HR 11.96, 95% CI: 8.13-17.60, p = 0.03). During a mean follow-up period of 6.8 ± 4.5 years, ARD patients with AF had a higher all cause death (16.5% vs. 2.1%, p < 0.001) and incidence of strokes (1.9% vs. 0.4%, p = 0.001) than non-AF patients. Conclusions The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up.

AB - Background: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). Methods: In 20,772 consecutive ARD patients (mean age 42 ± 17 years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. Results: AF was observed in 235 (1.1%) patients. The mean duration to AF diagnoses was 5.9 ± 2.4 years. Compared with patients without AF, AF patients were older, and had a higher CRP level (5.1 ± 0.7 vs. 2.7 ± 0.2 mg/L, p = 0.01), higher incidence of hypertension, heart failure and coronary artery disease. The AF prevalence was higher in inflammatory myositis (3.5%) and systemic sclerosis (2.3%) than that in other ARDs (all p < 0.05). In the multivariate analysis, the independent predictors of AF were an older age (HR 1.05, 95% CI: 1.04-1.06, p = 0.01), hypertension (HR 2.28, 95% CI: 1.70-3.06, p < 0.001), high CRP levels (HR 1.75, 95% CI: 1.07-2.86, p = 0.04), and heart failure (HR 11.96, 95% CI: 8.13-17.60, p = 0.03). During a mean follow-up period of 6.8 ± 4.5 years, ARD patients with AF had a higher all cause death (16.5% vs. 2.1%, p < 0.001) and incidence of strokes (1.9% vs. 0.4%, p = 0.001) than non-AF patients. Conclusions The incidence of AF in ARD was affected by specific disease and an inflammatory status manifested by the CRP level. AF in ARD was related to a higher mortality and strokes mandating meticulous follow-up.

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