Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea

Hwan Shin Jeong, Jung Jung Hee, Ran Kim Hye, Joseph Jeong, Hoon Jeong Seok, Sunjoo Kim, Yup Lee Eun, Nyeo Lee Jeong, Ludgerus Chang Chulhun

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofioxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofioxacin with reserpine was highly specific for efflux screening.

Original languageEnglish
Pages (from-to)2625-2627
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

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Molecular Epidemiology
Reserpine
Quinolones
Fluoroquinolones
Macrolides
Erythromycin
Tertiary Healthcare
Korea
Streptococcus pneumoniae
Tertiary Care Centers
Amino Acids
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Jeong, Hwan Shin ; Hee, Jung Jung ; Hye, Ran Kim ; Jeong, Joseph ; Seok, Hoon Jeong ; Kim, Sunjoo ; Eun, Yup Lee ; Jeong, Nyeo Lee ; Chulhun, Ludgerus Chang. / Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. In: Antimicrobial agents and chemotherapy. 2007 ; Vol. 51, No. 7. pp. 2625-2627.
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Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. / Jeong, Hwan Shin; Hee, Jung Jung; Hye, Ran Kim; Jeong, Joseph; Seok, Hoon Jeong; Kim, Sunjoo; Eun, Yup Lee; Jeong, Nyeo Lee; Chulhun, Ludgerus Chang.

In: Antimicrobial agents and chemotherapy, Vol. 51, No. 7, 01.07.2007, p. 2625-2627.

Research output: Contribution to journalArticle

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T1 - Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea

AU - Jeong, Hwan Shin

AU - Hee, Jung Jung

AU - Hye, Ran Kim

AU - Jeong, Joseph

AU - Seok, Hoon Jeong

AU - Kim, Sunjoo

AU - Eun, Yup Lee

AU - Jeong, Nyeo Lee

AU - Chulhun, Ludgerus Chang

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AB - The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofioxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofioxacin with reserpine was highly specific for efflux screening.

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