Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea

Hwan Shin Jeong, Jung Jung Hee, Ran Kim Hye, Joseph Jeong, Hoon Jeong Seok, Sunjoo Kim, Yup Lee Eun, Nyeo Lee Jeong, Ludgerus Chang Chulhun

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14 Citations (Scopus)

Abstract

The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofioxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofioxacin with reserpine was highly specific for efflux screening.

Original languageEnglish
Pages (from-to)2625-2627
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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