Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine: A Nested Case-Control Cohort Study

Bong Ju Moon, Sun Kyu Choi, DongAh Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Yoon Ha

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people. Methods: A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed. Results: Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199–371 per 1 million people. Overall crude mortality rate was 7.64%. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (P < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (P < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (P < 0.05) were significantly associated with surgery. Conclusions: Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.

Original languageEnglish
Pages (from-to)e323-e328
JournalWorld Neurosurgery
Volume117
DOIs
Publication statusPublished - 2018 Sep 1

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Ossification of Posterior Longitudinal Ligament
Case-Control Studies
Comorbidity
Spine
Cohort Studies
Mortality
Incidence
Cerebrovascular Disorders
Renal Hypertension
National Health Programs
Cardiovascular Diseases
Survival Rate
Hypertension
Kidney
Insurance
Sex Characteristics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

@article{1b2f226a9a164076a26446993093f87b,
title = "Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine: A Nested Case-Control Cohort Study",
abstract = "Objective: To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people. Methods: A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed. Results: Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199–371 per 1 million people. Overall crude mortality rate was 7.64{\%}. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (P < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (P < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (P < 0.05) were significantly associated with surgery. Conclusions: Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.",
author = "Moon, {Bong Ju} and Choi, {Sun Kyu} and DongAh Shin and Seong Yi and Kim, {Keung Nyun} and Yoon, {Do Heum} and Yoon Ha",
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Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine : A Nested Case-Control Cohort Study. / Moon, Bong Ju; Choi, Sun Kyu; Shin, DongAh; Yi, Seong; Kim, Keung Nyun; Yoon, Do Heum; Ha, Yoon.

In: World Neurosurgery, Vol. 117, 01.09.2018, p. e323-e328.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence, Incidence, Comorbidity, and Mortality Rates of Ossification of Posterior Longitudinal Ligament in the Cervical Spine

T2 - A Nested Case-Control Cohort Study

AU - Moon, Bong Ju

AU - Choi, Sun Kyu

AU - Shin, DongAh

AU - Yi, Seong

AU - Kim, Keung Nyun

AU - Yoon, Do Heum

AU - Ha, Yoon

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people. Methods: A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed. Results: Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199–371 per 1 million people. Overall crude mortality rate was 7.64%. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (P < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (P < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (P < 0.05) were significantly associated with surgery. Conclusions: Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.

AB - Objective: To evaluate prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL) using data from a 12-year national cohort of 1,025,340 Korean people. Methods: A nested case-control cohort study was performed from 2002 to 2013 using the insurance claims database provided by the National Health Insurance Service. We examined prevalence and incidence of cervical OPLL. Age- and sex-matched control subjects were randomly extracted, with 10 times the number of OPLL cases. Differences in sex, comorbidity, and relative survival rate compared with control subjects were assessed. Results: Cumulative prevalence was 20,960 per 1,025,340 people for 12 years. Annual incidence was approximately 199–371 per 1 million people. Overall crude mortality rate was 7.64%. Relative survival rate of OPLL cases was not significantly different from control cases. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases (P < 0.001). Additionally, between dead and surviving patients among OPLL cases, all comorbidities correlated more significantly with death (P < 0.001). Furthermore, between surgery and nonsurgery cases of OPLL, diabetes, hypertension, and renal disease (P < 0.05) were significantly associated with surgery. Conclusions: Annual incidence of OPLL was 199–371 per 1,025,340 people for 10 years. Diabetes, hypertension, cardiovascular disease, and cerebrovascular disease, except renal disease, correlated significantly with OPLL compared with control cases. Especially, diabetes, hypertension, and renal disease were associated with patients with OPLL who underwent surgery.

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