Prevalence of anti-β2 glycoprotein-I antibody in patients with primary or secondary immune thrombocytopenia

Kyung Soon Song, Young Ah Kim, Hyon Suk Kim, Jae Gyun Lim, Hyun Kyung Kim, Kwang Il Park, Quehn Park

Research output: Contribution to journalArticle

Abstract

We determined the prevalence of antibodies to β2 glycoprotein-I (β2GPI) in sera of 57 patients with primary or secondary immune thrombocytopenia positive for platelet antibody (PAIgG) and in 16 healthy control subjects. Both isotypes (IgG and IgM) of anti-β2GPI were detected by means of semiquantitative ELISA and platelet antibodies were measured by means of flow cytometry using FITC-labeled anti-human IgG. Six (10.5%) of 57 patients with immune thrombocytopenia had anti-β2GPI, whereas none of the 16 healthy subjects had anti-β2GPI. Four were positive for IgM anti-β2GPI, one for IgG anti-β2GPI, and one was positive both for IgM and IgG anti-β2GPI. There was no significant association between the presence of anti-β2GPI and the severity of thrombocytopenia. Our findings suggest that some patients with immune thrombocytopenia have anti-β2GPI in addition to the increased PAIgG; however, the results do not support a major role for anti-β2GPI in the pathogenesis of immune thrombocytopenia.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalPlatelets
Volume10
Issue number4
DOIs
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Hematology

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