Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea: A nationwide multicenter study

Jong Kuk Kim, Jong Seok Bae, Dae Seong Kim, Susumu Kusunoki, Jong Eun Kim, Ji Soo Kim, Young Eun Park, Ki Jong Park, Hyun Seok Song, Sun Young Kim, Jeong Geun Lim, Nam Hee Kim, Bum Chun Suh, Tai Seung Nam, Min Su Park, Youngchul Choi, Eun Hee Sohn, Sang Jun Na, So Young Huh, Ohyun KwonSu Yun Lee, Sung Hoon Lee, Sun Young Oh, Seong Hae Jeong, Tae Kyeong Lee, Dong Uk Kim

Research output: Contribution to journalArticle

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Abstract

Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti- GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti- GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Volume10
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Gangliosides
Korea
Multicenter Studies
Anti-Idiotypic Antibodies
Immunoglobulin G
Guillain-Barre Syndrome
Antibodies
Ophthalmoplegia
Cranial Nerves
Facial Nerve
Diagnostic Errors
Serum
Signs and Symptoms
Immunoglobulin M

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kim, Jong Kuk ; Bae, Jong Seok ; Kim, Dae Seong ; Kusunoki, Susumu ; Kim, Jong Eun ; Kim, Ji Soo ; Park, Young Eun ; Park, Ki Jong ; Song, Hyun Seok ; Kim, Sun Young ; Lim, Jeong Geun ; Kim, Nam Hee ; Suh, Bum Chun ; Nam, Tai Seung ; Park, Min Su ; Choi, Youngchul ; Sohn, Eun Hee ; Na, Sang Jun ; Huh, So Young ; Kwon, Ohyun ; Lee, Su Yun ; Lee, Sung Hoon ; Oh, Sun Young ; Jeong, Seong Hae ; Lee, Tae Kyeong ; Kim, Dong Uk. / Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea : A nationwide multicenter study. In: Journal of Clinical Neurology (Korea). 2014 ; Vol. 10, No. 2. pp. 94-100.
@article{834bb18e1ee04e76bb3ead1f5897207d,
title = "Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barr{\'e} syndrome in Korea: A nationwide multicenter study",
abstract = "Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barr{\'e} syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50{\%}). The most frequent type was IgG anti- GM1 antibody (47{\%}), followed by IgG anti-GT1a (38{\%}), IgG anti-GD1a (25{\%}), and IgG anti- GQ1b (8{\%}) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68{\%} of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.",
author = "Kim, {Jong Kuk} and Bae, {Jong Seok} and Kim, {Dae Seong} and Susumu Kusunoki and Kim, {Jong Eun} and Kim, {Ji Soo} and Park, {Young Eun} and Park, {Ki Jong} and Song, {Hyun Seok} and Kim, {Sun Young} and Lim, {Jeong Geun} and Kim, {Nam Hee} and Suh, {Bum Chun} and Nam, {Tai Seung} and Park, {Min Su} and Youngchul Choi and Sohn, {Eun Hee} and Na, {Sang Jun} and Huh, {So Young} and Ohyun Kwon and Lee, {Su Yun} and Lee, {Sung Hoon} and Oh, {Sun Young} and Jeong, {Seong Hae} and Lee, {Tae Kyeong} and Kim, {Dong Uk}",
year = "2014",
month = "1",
day = "1",
doi = "10.3988/jcn.2014.10.2.94",
language = "English",
volume = "10",
pages = "94--100",
journal = "Journal of Clinical Neurology (Korea)",
issn = "1738-6586",
publisher = "Korean Neurological Association",
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Kim, JK, Bae, JS, Kim, DS, Kusunoki, S, Kim, JE, Kim, JS, Park, YE, Park, KJ, Song, HS, Kim, SY, Lim, JG, Kim, NH, Suh, BC, Nam, TS, Park, MS, Choi, Y, Sohn, EH, Na, SJ, Huh, SY, Kwon, O, Lee, SY, Lee, SH, Oh, SY, Jeong, SH, Lee, TK & Kim, DU 2014, 'Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea: A nationwide multicenter study', Journal of Clinical Neurology (Korea), vol. 10, no. 2, pp. 94-100. https://doi.org/10.3988/jcn.2014.10.2.94

Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea : A nationwide multicenter study. / Kim, Jong Kuk; Bae, Jong Seok; Kim, Dae Seong; Kusunoki, Susumu; Kim, Jong Eun; Kim, Ji Soo; Park, Young Eun; Park, Ki Jong; Song, Hyun Seok; Kim, Sun Young; Lim, Jeong Geun; Kim, Nam Hee; Suh, Bum Chun; Nam, Tai Seung; Park, Min Su; Choi, Youngchul; Sohn, Eun Hee; Na, Sang Jun; Huh, So Young; Kwon, Ohyun; Lee, Su Yun; Lee, Sung Hoon; Oh, Sun Young; Jeong, Seong Hae; Lee, Tae Kyeong; Kim, Dong Uk.

In: Journal of Clinical Neurology (Korea), Vol. 10, No. 2, 01.01.2014, p. 94-100.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea

T2 - A nationwide multicenter study

AU - Kim, Jong Kuk

AU - Bae, Jong Seok

AU - Kim, Dae Seong

AU - Kusunoki, Susumu

AU - Kim, Jong Eun

AU - Kim, Ji Soo

AU - Park, Young Eun

AU - Park, Ki Jong

AU - Song, Hyun Seok

AU - Kim, Sun Young

AU - Lim, Jeong Geun

AU - Kim, Nam Hee

AU - Suh, Bum Chun

AU - Nam, Tai Seung

AU - Park, Min Su

AU - Choi, Youngchul

AU - Sohn, Eun Hee

AU - Na, Sang Jun

AU - Huh, So Young

AU - Kwon, Ohyun

AU - Lee, Su Yun

AU - Lee, Sung Hoon

AU - Oh, Sun Young

AU - Jeong, Seong Hae

AU - Lee, Tae Kyeong

AU - Kim, Dong Uk

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti- GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti- GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.

AB - Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti- GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti- GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.

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