Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea: A nationwide multicenter study

Jong Kuk Kim, Jong Seok Bae, Dae Seong Kim, Susumu Kusunoki, Jong Eun Kim, Ji Soo Kim, Young Eun Park, Ki Jong Park, Hyun Seok Song, Sun Young Kim, Jeong Geun Lim, Nam Hee Kim, Bum Chun Suh, Tai Seung Nam, Min Su Park, Young Chul Choi, Eun Hee Sohn, Sang Jun Na, So Young Huh, Ohyun KwonSu Yun Lee, Sung Hoon Lee, Sun Young Oh, Seong Hae Jeong, Tae Kyeong Lee, Dong Uk Kim

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Abstract

Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti- GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti- GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalJournal of Clinical Neurology (Korea)
Volume10
Issue number2
DOIs
Publication statusPublished - 2014 Apr

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Kim, J. K., Bae, J. S., Kim, D. S., Kusunoki, S., Kim, J. E., Kim, J. S., Park, Y. E., Park, K. J., Song, H. S., Kim, S. Y., Lim, J. G., Kim, N. H., Suh, B. C., Nam, T. S., Park, M. S., Choi, Y. C., Sohn, E. H., Na, S. J., Huh, S. Y., ... Kim, D. U. (2014). Prevalence of anti-ganglioside antibodies and their clinical correlates with guillain-barré syndrome in Korea: A nationwide multicenter study. Journal of Clinical Neurology (Korea), 10(2), 94-100. https://doi.org/10.3988/jcn.2014.10.2.94